ID H0WFM9_OTOGA Unreviewed; 1049 AA.
AC H0WFM9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=RAS p21 protein activator 1 {ECO:0000313|Ensembl:ENSOGAP00000000050.2};
GN Name=RASA1 {ECO:0000313|Ensembl:ENSOGAP00000000050.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000000050.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000000050.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03040410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03040414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WFM9; -.
DR STRING; 30611.ENSOGAP00000000050; -.
DR Ensembl; ENSOGAT00000000055.2; ENSOGAP00000000050.2; ENSOGAG00000000055.2.
DR eggNOG; KOG3508; Eukaryota.
DR GeneTree; ENSGT00940000155846; -.
DR HOGENOM; CLU_010968_1_0_1; -.
DR InParanoid; H0WFM9; -.
DR OMA; ICGCLQR; -.
DR TreeFam; TF105301; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051020; F:GTPase binding; IEA:Ensembl.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0048514; P:blood vessel morphogenesis; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd13260; PH_RASA1; 1.
DR CDD; cd05391; RasGAP_p120GAP; 1.
DR CDD; cd10354; SH2_Cterm_RasGAP; 1.
DR CDD; cd10353; SH2_Nterm_RasGAP; 1.
DR CDD; cd11788; SH3_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR035842; RasGAP_C_SH2.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035841; RasGAP_N_SH2.
DR InterPro; IPR035652; RasGAP_SH3.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 182..273
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 280..342
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 352..442
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 475..579
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 579..692
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 750..944
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 1049 AA; 116383 MW; 0558DAB9B372B7FD CRC64;
MMAAEAGSEE GGPVTAGAGG GGAAAGSSAY PAVCRVKIPA ALPVAAAPYP GLVEAGVAGT
LGSGAALGPG FLGAGSVAGT LGGAGLTGGG AAAGVAGAAA AGVAGGVAAG PSGEMALTKV
TTSLPADTLG SGCGFPPLPP PPQLPPLGAS LGTVDEGDSL DGPEYEEEEV AIPLTAPPTN
QWYHGKLDRT IAEERLRQAG KSGSYLIRES DRRPGSFVLS FLSQTNVVNH FRIIAMCGDY
YIGGRRFSSL SDLIGYYSHV SCLLKGEKLL YPVAPPEPVE DRRRVRAILP YTKVPETDEI
SFLKGDMFIV HNELDDGWIW VTNLRTDEQG LIVDDLVEEV GREEDPHEGK IWFHGKISKQ
EAYNLLMTVG QVCSFLVRPS DNTPGDYSLY FRTNENIQRF KICPTPNNQF MMGGRYYNSI
ADIIDHYRKE QIVEGYYLKE PVPMQDQEQV LNDTVDGKEI YNTIRRKTKD AFYKNIVKKG
YLLKKAGKGK RWKNLYFILE GSDAQLIYFE SEKRATKPKG LIDLSVCSVY VVHDSLFGRP
NCFQIVVQHF SEEHYIFYFA GETPEQAEDW MKGLQAFCSL RKSSPGTSNK RLRQVSSLIL
HIEEAHKLPV KHFTNPYCNI YLNSVQVAKT HAREGQNPVW SEEFVFDDLP PDINRFEITL
SNKTKKSKDP DILFMRCQLS RLQKGHATDE WFLLSSHIPL KGIEPGSLRV RARYSMEKIM
PEEEYSEFKE LILQKELHVV YALSHVCGQD RTLLASILLR IFLHEKLESL LLCTLNDREI
SMEDEATTLF RATTLASTLM EQYMKATATQ FVHHALKDSI LKIMESKQSC ELSPSKLEKN
EDVNTNLAHL LNILSELVEK IFMASEILPP TLRYIYGCLQ KSVQHKWPTN TTMRTRVVSG
FVFLRLICPA ILNPRMFNII SDSPSPIAAR TLILVAKSVQ NLANLVEFGA KEPYMEGVNP
FIKSNKHRMI MFLDELGNVP ELPDTTEHSR TDLSRDLAAL HEICVAHSDE LRTLSNDRGA
QQHVLKKLLA ITELLQQKQN QYTKTNDIR
//
