ID H0WFW2_OTOGA Unreviewed; 1706 AA.
AC H0WFW2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=5'-3' exoribonuclease 1 {ECO:0000256|PIRNR:PIRNR006743};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR006743};
GN Name=XRN1 {ECO:0000313|Ensembl:ENSOGAP00000000151.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000000151.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000000151.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family.
CC {ECO:0000256|PIRNR:PIRNR006743}.
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DR EMBL; AAQR03062757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000000151; -.
DR Ensembl; ENSOGAT00000000170.2; ENSOGAP00000000151.2; ENSOGAG00000000170.2.
DR eggNOG; KOG2045; Eukaryota.
DR GeneTree; ENSGT00670000098080; -.
DR HOGENOM; CLU_001581_3_0_1; -.
DR InParanoid; H0WFW2; -.
DR OMA; VASWPWF; -.
DR TreeFam; TF105757; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:GOC.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0071044; P:histone mRNA catabolic process; IEA:Ensembl.
DR GO; GO:0071028; P:nuclear mRNA surveillance; IEA:Ensembl.
DR GO; GO:0016075; P:rRNA catabolic process; IEA:Ensembl.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 2.170.260.40; -; 1.
DR Gene3D; 2.30.30.750; -; 1.
DR Gene3D; 3.40.50.12390; -; 1.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR016494; 5_3_exoribonuclease_1.
DR InterPro; IPR041385; SH3_12.
DR InterPro; IPR040992; XRN1_D1.
DR InterPro; IPR047007; XRN1_D1_sf.
DR InterPro; IPR041106; XRN1_D2_D3.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR047008; XRN1_SH3_sf.
DR PANTHER; PTHR12341:SF41; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF18129; SH3_12; 1.
DR Pfam; PF18332; XRN1_D1; 1.
DR Pfam; PF18334; XRN1_D2_D3; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF006743; Exonuclease_Xnr1; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR006743};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR006743};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR006743};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR006743};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR006743}.
FT DOMAIN 1..227
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 272..597
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT DOMAIN 652..844
FT /note="5'-3' exoribonuclease 1 D1"
FT /evidence="ECO:0000259|Pfam:PF18332"
FT DOMAIN 850..1075
FT /note="Exoribonuclease Xrn1 D2/D3"
FT /evidence="ECO:0000259|Pfam:PF18334"
FT DOMAIN 1102..1171
FT /note="5'-3' exoribonuclease 1 SH3-like"
FT /evidence="ECO:0000259|Pfam:PF18129"
FT REGION 1382..1407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1619..1706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1619..1693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1706 AA; 193833 MW; 843F29A34ADD170A CRC64;
MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISDDKI
FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKAIEKGE
TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNMKISTDKS WQGVTIYFSG HETPGEGEHK
IMEFIRSEKA KPDHDPNTRH CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKAQRVCA
PEETTFHLLH LSLMREYIDY EFSVLKEKIT FKYDIERIID DWILMGFLVG NDFIPHLPHL
HINHDALPLL YGTYITILPE LGGYINESGH LNLPRFEKYL VKLSDFDREH FSEVFVDLKW
FESKVGNKYL NEAAGVAAEE AKNYKEKKKS KGPENSICWA ALEKNKGEVV TSKDNLEDET
EDDDLFETEF RQYKRTYYMT KMGVDVVSDD FLANQAACYV QAIQWILHYY YHGVQSWSWY
YPYHYAPFLS DIRNISTLKI HFELGKPFKP FEQLLAVLPA ASKNLLPTCY QNLMILSTSI
LIAHCPFHFF VCVCETESHY VALSRVPYLD FKRLLEAMEA CNHSLKKEEK KRNQHSECLM
CWYDGDTEFT YPSPWPEKFP AVERCCTRYK IISLDAWRVD INKNKITKVD QKALYFCGFP
TLKNIKHKFF LKKSGVQVFQ QSSRGENMML EILMNAESDE LSIENVASSV LGKSVFVNWP
HLEEARVVAV SDGETKFFLE EPPGTQKLYL GRTAPPSKVV HLGDKEQSNW TKEVQGISEH
YLRRKGIIIN ETSAVVYAQL LTGRKYQVNQ NGDVRLEKQW SKQVVPFVYQ TVVQDIRAFD
SRFSNIKTLD DLFPPRSMVF MLGTPYYGCT GEVQDSGDVI TEGRIRVVFS IPCEPNLDAL
IQNQHKYSIK YNPGYVLASR LGVSGYLVSR FTGSIFIGRG SRRNPHGDHK ANVGLNLKFN
KKNEEVPGYT KKVGSEWMYS SAAEQLLAEY LERAPELFSY ISKNSQEDVF YEDDIWPGEN
ENGAEKVQEI ITWLKGHPVS TLSRSSCDLQ ILDAAIVEKI EEEVEKCKQR KNNKKVRVTV
KPHLLYRPLE QQHGVIPDRD AEFRLFDRVV NVRENFSVPV GLRGTIIGIK GANREADVLF
EVLFDEEFPG GLTIRCSPGR GYRLPTSALV NLSHGTRSET GNQKLTAIVK PQPAVNHYSS
NSPISSGHLG GLNHSPQSLF VPAHVPAKDD DEFCNIWQSL QGSSKIQHFQ STIQEKGTVL
PQEIRQVNQH HKSGFNDNNI KYQQRKHDPH RKFKEECKSP KAECQSQKIS NKQTNSGIEN
FLVSLNISKE NEVQSSHHGE SPSEEHLSPQ SFAMGTRMLK EILKIDGSDT VDHKKEIKQF
GNEVTVSSNR RDDYRSSPQP KQNKKLASYV NKPHSVNEYH NIQSMDNVCW PAPSQIPPIS
TPVTELSRIC SLIGMPQPDF SFLRTPQTMT VCQVKLSNGL LVHGPQCHSE NEAKEKAALF
ALQQLGSLGV NFPLPPPVFT NYPSAISPRS ITPVFPQTTG WDHYGSNLAL GAANIMPSSS
HLFGSMPWGP PVPVPGKPFH HALYSGTMPM AGGVPSAMHT QFIPLQVTKK RVANKKNFEN
KEVQSSSQAT PLQTSQLESS DVTKVIPQDN SSASLKSSQT AQAASSLQVE TASQGRSVSQ
PKSTSSSSRR KSRKLAVNFG ASKPSE
//
