ID H0WG72_OTOGA Unreviewed; 1025 AA.
AC H0WG72;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Myosin IG {ECO:0000313|Ensembl:ENSOGAP00000000291.2};
GN Name=MYO1G {ECO:0000313|Ensembl:ENSOGAP00000000291.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000000291.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000000291.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AAQR03137232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WG72; -.
DR STRING; 30611.ENSOGAP00000000291; -.
DR Ensembl; ENSOGAT00000000327.2; ENSOGAP00000000291.2; ENSOGAG00000000326.2.
DR eggNOG; KOG0160; Eukaryota.
DR eggNOG; KOG0164; Eukaryota.
DR GeneTree; ENSGT00940000158053; -.
DR HOGENOM; CLU_000192_7_7_1; -.
DR InParanoid; H0WG72; -.
DR OMA; YMILRKY; -.
DR TreeFam; TF312960; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0030175; C:filopodium; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0031256; C:leading edge membrane; IEA:Ensembl.
DR GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001891; C:phagocytic cup; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0071976; P:cell gliding; IEA:Ensembl.
DR GO; GO:0031589; P:cell-substrate adhesion; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0006887; P:exocytosis; IEA:Ensembl.
DR GO; GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; IEA:Ensembl.
DR GO; GO:0120117; P:T cell meandering migration; IEA:Ensembl.
DR GO; GO:0002456; P:T cell mediated immunity; IEA:Ensembl.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF381; UNCONVENTIONAL MYOSIN-IG; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 15..714
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 831..1024
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 591..613
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 108..115
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1025 AA; 116990 MW; 7E52CF3ABCFD403F CRC64;
VVPAGGMEDS EGPEYGKPDF VLLDQMTMED FMRNLQLRFK KGRIYTYIGE VLVSVNPYQE
LPLYGPEAIA KYQGRELYER PPHLYAVANA AYKAMKRRSR DTCIVISGES GAGKTEASKH
IMQYIAAVTN PSQRAEVERV KDVLLKSTCV LEAFGNARTN RNHNSSRFGK YMDINFDFKG
DPIGGHIHSY LLEKSRVLKQ HVGERNFHAF YQLLRGSDDK ELHEMHLERN PALYNFTRQG
AGLSMGVHSA LDSDERSHQA VTEAMRVIGF SSEEVGSVYR ILAAILHLGN IEFVETEEGG
MQKGGLVVAQ EALVDHVAEL TATPRDLVLR TLLARTVASG GREVIEKGHT AAEASYARDA
CAKAVYQRLF EWVVDKINSI MEARDRDPRR DGKDTVIGVL DIYGFEVFPV NSFEQFCINY
CNEKLQQLFI QLILKQEQEE YEREGITWQS VEYFNNATIV DLVERPHRGI LAVLDEACSA
AGTITDRIFL QSLDAYHRHH PHYTSRQLCP TDKTMEFGRD FRIKHYAGDV TYSVEGFIDK
NRDFLFQDFK RLLYNSSMDP TLRAMWPEGQ QDITEVTKRP LTAGTLFKNS MVALVENLAS
KEPFYVRCIK PNEDKVAGRL DEDHCRHQVA YLGLLENVRV RRAGFASRQP YSRFLLRYKM
TCEYTWPNHL LGSDKAAVSA LLEQHGLQGD VAFGHSKLFI RSPRTLVTLE QSRARLIPII
VLLLQKAWRG TLARWHCRRL RAVYTIMRGF RRYKVRAHLA ELQRRFQAAR QPPLYGRDLV
WPPPPTVLQP FQDTCQALFC RWRARQLVKN IPPSDMAQIK AKVAAMGALQ GLRQDWGCRR
AWNRDYLSSA TDNPTASSLF AQQLKKLREK DGFGTVLFSS HVRKVNRFHK RRDRALLLTD
RHLYKLEPSR QYRVMRAVPL DRVTGLSVTS GRDQLVVLHA RGQDDLVVCL HRSQPPLDNR
IGELVGVLSA HCQGEGRALE VRVSDCIPLS QRGARRLVSV EPRPEQPEPD FCCVRGTFTL
LWPSH
//
