ID H0WGH0_OTOGA Unreviewed; 529 AA.
AC H0WGH0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Cyclin L2 {ECO:0008006|Google:ProtNLM};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000000421.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000000421.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin L subfamily.
CC {ECO:0000256|ARBA:ARBA00010589}.
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DR EMBL; AAQR03101056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03101057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WGH0; -.
DR STRING; 30611.ENSOGAP00000000421; -.
DR Ensembl; ENSOGAT00000000470.2; ENSOGAP00000000421.2; ENSOGAG00000000469.2.
DR eggNOG; KOG0835; Eukaryota.
DR GeneTree; ENSGT00940000159239; -.
DR HOGENOM; CLU_022000_6_1_1; -.
DR InParanoid; H0WGH0; -.
DR OMA; QEICMET; -.
DR TreeFam; TF101011; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IEA:UniProt.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20590; CYCLIN_CCNL2_rpt1; 1.
DR CDD; cd20593; CYCLIN_CCNL2_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF45; CYCLIN-L2; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF036580; Cyclin_L; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 91..193
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 202..341
FT /note="Cyclin C-terminal"
FT /evidence="ECO:0000259|SMART:SM01332"
FT DOMAIN 206..290
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 324..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 59285 MW; DE60193DEB5014F4 CRC64;
EPKGTRKHKM AAAAATGAPG SAAPAAVAGA PGSGSAAPGL QGVLIGDRLY SGVLITLENC
LLPDDKLRFT PSMSSGLDTH TETDLRVVGC ELIQAAGILL RLPQVAMATG QVLFQRFFYT
KSFVKHSMEH VSMACVHLAS KIEEAPRRIR DVINVFHRLR QLREKKKLVP LLLDQDYVNL
KNQIIKAERR VLKELGFCVH VKHPHKIIVM YLQVLECERN QHLVQTSWNY MNDSLRTDVF
VRFQPESIAC ACIYLAARTL EIPLPSRPHW FLLFGATEEE IQEICLKILQ LYTRKKVDLT
HLEGEVEKRK HAIEEAKAQA RGLLSGGAQA ADSTAGFSPA PKLVESPKEG KGNKASPLSV
KSTKRRIEGM KKTKADSPVN GLPKGRESRS RSRSREQSYS RSPSRSASPK RRKSDSGSTS
GHSKSQSRSR SRSDSPPRQV HRSAPYKGSE VKGSRKSKDC KCPTQKPHKS QSRSSSRSRS
RSRERADNAG KYKKKSHYYR DQPRERARSY ERTGHRYERD HPGHSRHRR
//
