ID H0WGM7_OTOGA Unreviewed; 216 AA.
AC H0WGM7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=DNA replication complex GINS protein PSF3 {ECO:0000256|RuleBase:RU367161};
GN Name=GINS3 {ECO:0000313|Ensembl:ENSOGAP00000000484.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000000484.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000000484.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC DNA replication. {ECO:0000256|RuleBase:RU367161}.
CC -!- SUBUNIT: Component of the GINS complex.
CC {ECO:0000256|RuleBase:RU367161}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367161}.
CC -!- SIMILARITY: Belongs to the GINS3/PSF3 family.
CC {ECO:0000256|ARBA:ARBA00006343, ECO:0000256|RuleBase:RU367161}.
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DR EMBL; AAQR03092981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003792637.1; XM_003792589.2.
DR AlphaFoldDB; H0WGM7; -.
DR STRING; 30611.ENSOGAP00000000484; -.
DR Ensembl; ENSOGAT00000000541.2; ENSOGAP00000000484.2; ENSOGAG00000000540.2.
DR GeneID; 100951569; -.
DR KEGG; oga:100951569; -.
DR CTD; 64785; -.
DR eggNOG; KOG1106; Eukaryota.
DR GeneTree; ENSGT00390000001622; -.
DR HOGENOM; CLU_081646_2_0_1; -.
DR InParanoid; H0WGM7; -.
DR OMA; IYKEGWR; -.
DR OrthoDB; 3670282at2759; -.
DR TreeFam; TF314626; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0071162; C:CMG complex; IEA:Ensembl.
DR GO; GO:0000811; C:GINS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
DR CDD; cd11713; GINS_A_psf3; 1.
DR CDD; cd21693; GINS_B_Psf3; 1.
DR Gene3D; 1.20.58.2050; -; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR010492; GINS_Psf3.
DR InterPro; IPR038437; GINS_Psf3_sf.
DR PANTHER; PTHR22768:SF0; DNA REPLICATION COMPLEX GINS PROTEIN PSF3; 1.
DR PANTHER; PTHR22768; UNCHARACTERIZED; 1.
DR Pfam; PF05916; Sld5; 1.
DR SUPFAM; SSF158573; GINS helical bundle-like; 1.
DR SUPFAM; SSF160059; PriA/YqbF domain; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU367161};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367161};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 67..173
FT /note="GINS subunit"
FT /evidence="ECO:0000259|Pfam:PF05916"
SQ SEQUENCE 216 AA; 24507 MW; B021733C6C5D1E86 CRC64;
MSEAYFRVES GALGPEENFL SLDDILMSHE KLPVRTEIAI PRLGSFFLER SAAADTDNAV
PQGSKLELPL WLAKGLFDNK RRILSVELPK IYQEGWRTVF SADANVVDLH KMGPHFYGFG
SQLLHFDSPE TTDISQSLLQ TFIGRFRRIM DSSQNAYNED TSALVARLDE MERGLFQTGQ
KGLNDFQSWE KGQASQITAS SLVQNYKKRK FMVMED
//
