ID H0WHU7_OTOGA Unreviewed; 549 AA.
AC H0WHU7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Tripartite motif containing 55 {ECO:0000313|Ensembl:ENSOGAP00000000967.2};
GN Name=TRIM55 {ECO:0000313|Ensembl:ENSOGAP00000000967.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000000967.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000000967.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03133692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03133693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03133694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WHU7; -.
DR STRING; 30611.ENSOGAP00000000967; -.
DR Ensembl; ENSOGAT00000001083.2; ENSOGAP00000000967.2; ENSOGAG00000001083.2.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000154004; -.
DR HOGENOM; CLU_013137_5_3_1; -.
DR InParanoid; H0WHU7; -.
DR OMA; CDIHEDE; -.
DR TreeFam; TF331669; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0050904; P:diapedesis; IEA:Ensembl.
DR GO; GO:0002523; P:leukocyte migration involved in inflammatory response; IEA:Ensembl.
DR GO; GO:1905517; P:macrophage migration; IEA:Ensembl.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR CDD; cd19832; Bbox2_MuRF2_C-II; 1.
DR CDD; cd16760; RING-HC_MuRF2; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017903; COS_domain.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF640; TRIPARTITE MOTIF-CONTAINING PROTEIN 55; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51262; COS; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 26..84
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 121..163
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 271..329
FT /note="COS"
FT /evidence="ECO:0000259|PROSITE:PS51262"
FT REGION 328..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..357
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 60516 MW; 955D3EAFBCE7AE86 CRC64;
MSASLNYKSF SKEQQTMDNL EKQLICPICL EMFTKPVVIL PCQHNLCRKC ASDIFQEQAS
NPYLPTRGGT TVASGGRFRC PSCRHEVVLD RHGVYGLQRN LLVENIIDIY KQESTRPEKK
SDQPVCEEHE EERINIYCLN CEVPTCSLCK VFGAHKDCQV APLTHVFQRQ KSELSNGIAV
LVGSNDRVQG VISELEDTCK IIEECCRKQK QELCEKFDYL YGILEERKNE MTQVITRTQE
EKLEHVRALI KKYSDHLENV TKLVESGIQF MDEPEMAVFL QNAKTLLQKI SEASKAFQME
KIEHGYENMN HFTVNLNREE KIIREIDFYR EEEEEEEEGG EGEREEGEEE GEVEVEEVEN
GPTVAPGEDA SLGRALEPSQ LSSELQAATG ALPASSPEPP PALPPAADAP VTQGEVVPTG
SQQTTESETP VLAAADTADP LFYPSWYKGQ TRKATTNPPC TPGSEVLGQI GPPGSEDSNV
QNAEVAGAAS QERAAVSGKE TSAPAATSQI GFETPPLQGQ AAASGSGNGA DSEPARHVFS
FSWLNSLNE
//
