ID H0WHX2_OTOGA Unreviewed; 438 AA.
AC H0WHX2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Battenin {ECO:0000256|RuleBase:RU361113};
GN Name=CLN3 {ECO:0000313|Ensembl:ENSOGAP00000000997.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000000997.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000000997.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU361113}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the battenin family.
CC {ECO:0000256|ARBA:ARBA00007467, ECO:0000256|RuleBase:RU361113}.
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DR EMBL; AAQR03123101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03123102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003795819.1; XM_003795771.2.
DR AlphaFoldDB; H0WHX2; -.
DR STRING; 30611.ENSOGAP00000000997; -.
DR Ensembl; ENSOGAT00000001121.2; ENSOGAP00000000997.2; ENSOGAG00000001120.2.
DR GeneID; 100955261; -.
DR KEGG; oga:100955261; -.
DR CTD; 1201; -.
DR eggNOG; KOG3880; Eukaryota.
DR GeneTree; ENSGT00390000003249; -.
DR HOGENOM; CLU_029663_0_1_1; -.
DR InParanoid; H0WHX2; -.
DR OMA; WLCNWQV; -.
DR OrthoDB; 2912995at2759; -.
DR TreeFam; TF314055; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0044754; C:autolysosome; IEA:Ensembl.
DR GO; GO:0005901; C:caveola; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0031901; C:early endosome membrane; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0005795; C:Golgi stack; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0008021; C:synaptic vesicle; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
DR GO; GO:0120146; F:sulfatide binding; IEA:Ensembl.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0001508; P:action potential; IEA:Ensembl.
DR GO; GO:0042987; P:amyloid precursor protein catabolic process; IEA:Ensembl.
DR GO; GO:0008306; P:associative learning; IEA:Ensembl.
DR GO; GO:0097352; P:autophagosome maturation; IEA:Ensembl.
DR GO; GO:0061909; P:autophagosome-lysosome fusion; IEA:Ensembl.
DR GO; GO:0043534; P:blood vessel endothelial cell migration; IEA:Ensembl.
DR GO; GO:0046474; P:glycerophospholipid biosynthetic process; IEA:Ensembl.
DR GO; GO:0046836; P:glycolipid transport; IEA:Ensembl.
DR GO; GO:0090160; P:Golgi to lysosome transport; IEA:Ensembl.
DR GO; GO:0009992; P:intracellular water homeostasis; IEA:Ensembl.
DR GO; GO:0035235; P:ionotropic glutamate receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1903826; P:L-arginine transmembrane transport; IEA:Ensembl.
DR GO; GO:0007042; P:lysosomal lumen acidification; IEA:Ensembl.
DR GO; GO:0035752; P:lysosomal lumen pH elevation; IEA:Ensembl.
DR GO; GO:1905146; P:lysosomal protein catabolic process; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0045861; P:negative regulation of proteolysis; IEA:Ensembl.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR GO; GO:0090384; P:phagosome-lysosome docking; IEA:Ensembl.
DR GO; GO:0090385; P:phagosome-lysosome fusion; IEA:Ensembl.
DR GO; GO:0044857; P:plasma membrane raft organization; IEA:Ensembl.
DR GO; GO:2001288; P:positive regulation of caveolin-mediated endocytosis; IEA:Ensembl.
DR GO; GO:0042998; P:positive regulation of Golgi to plasma membrane protein transport; IEA:Ensembl.
DR GO; GO:0048549; P:positive regulation of pinocytosis; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0016485; P:protein processing; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR GO; GO:1900079; P:regulation of arginine biosynthetic process; IEA:Ensembl.
DR GO; GO:1901096; P:regulation of autophagosome maturation; IEA:Ensembl.
DR GO; GO:0016243; P:regulation of autophagosome size; IEA:Ensembl.
DR GO; GO:0106049; P:regulation of cellular response to osmotic stress; IEA:Ensembl.
DR GO; GO:0051493; P:regulation of cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0010762; P:regulation of fibroblast migration; IEA:Ensembl.
DR GO; GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:1905244; P:regulation of modification of synaptic structure; IEA:Ensembl.
DR GO; GO:1905162; P:regulation of phagosome maturation; IEA:Ensembl.
DR GO; GO:0070613; P:regulation of protein processing; IEA:Ensembl.
DR GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IEA:Ensembl.
DR GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IEA:Ensembl.
DR GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
DR GO; GO:0036359; P:renal potassium excretion; IEA:Ensembl.
DR GO; GO:0047496; P:vesicle transport along microtubule; IEA:Ensembl.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR003492; Battenin_disease_Cln3.
DR InterPro; IPR018460; Battenin_disease_Cln3_subgr.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10981; BATTENIN; 1.
DR PANTHER; PTHR10981:SF0; BATTENIN; 1.
DR Pfam; PF02487; CLN3; 1.
DR PIRSF; PIRSF015974; CLN3_BTN1; 1.
DR PRINTS; PR01315; BATTENIN.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|RuleBase:RU361113};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361113};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361113};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361113}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 98..122
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 128..145
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 181..200
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 212..230
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 284..308
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 344..365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 371..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 438 AA; 47581 MW; 028F5D2BEFBFE8A9 CRC64;
MEGRAGSRKR LLDSEGEETA PEPQTPLLDR QGSHWKNAVG FWLLGLCNNF SYVVMLSAAH
DILSQERAPG NQSHVHPSPA PIPHNSSSRF DCNPVSTAAV LLADILPTFI IKLVAPLGLH
LLPYSPRVLV SGLSAAGSFI LVAFSHSVGT SLCGVVLASI SSGLGEVTFL SLTAFYPRAV
ISWWSSGTGG AGLLGALSYL GLTEVGLSPQ HTLLSMLGIP ILLLASYFLL LTSPEPQDPG
GQEEAETAAR QPLIGTEAPE LKTGSSSGLS LQERWTVFKS LLKYVVPLVL VYFAEYFINQ
GLFELLFFRN ISLSHAQQYR WYQMLYQAGV FVSRSSLSCC RIPYVWALAV LQCLNLAFLL
ADMWFSFLPS IYLVFLIILF EGLLGGAAYV NTFHNIALET SDEHREFAME AACISDTLGI
SLSGLLALPL HNFLCHLS
//
