GenomeNet

Database: UniProt
Entry: H0WHX6_OTOGA
LinkDB: H0WHX6_OTOGA
Original site: H0WHX6_OTOGA 
ID   H0WHX6_OTOGA            Unreviewed;      3103 AA.
AC   H0WHX6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   07-OCT-2020, entry version 52.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000001001};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSOGAP00000001001};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001001, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000001001, ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000001001}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AAQR03176577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003802097.1; XM_003802049.1.
DR   STRING; 30611.ENSOGAP00000001001; -.
DR   Ensembl; ENSOGAT00000001125; ENSOGAP00000001001; ENSOGAG00000001123.
DR   GeneID; 100951736; -.
DR   CTD; 1063; -.
DR   eggNOG; ENOG502QVMD; Eukaryota.
DR   GeneTree; ENSGT00730000111187; -.
DR   HOGENOM; CLU_000551_0_0_1; -.
DR   InParanoid; H0WHX6; -.
DR   OMA; YNAQLVQ; -.
DR   OrthoDB; 205405at2759; -.
DR   TreeFam; TF101133; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 2.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 2.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN          1..307
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          2119..2258
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2301..2440
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2957..3001
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          208..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          252..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1659..1682
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1711..1738
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2891..2967
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3010..3103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          280..307
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          322..342
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          350..377
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          411..459
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          463..501
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          523..615
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          623..650
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          658..685
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          753..773
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          832..873
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          899..940
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          962..996
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1029..1088
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1118..1145
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1192..1233
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1275..1302
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1321..1341
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1386..1406
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1538..1590
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1613..1635
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1781..1843
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1878..1898
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1913..1947
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1958..1985
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1990..2031
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2046..2073
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2095..2122
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2130..2157
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2162..2220
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2224..2266
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2312..2339
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2347..2423
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2435..2469
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2505..2525
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2550..2598
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2617..2665
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2677..2704
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2706..2761
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2769..2817
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2824..2851
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2859..2879
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1659..1680
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2906..2930
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2943..2957
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3017..3066
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3067..3081
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3103 AA;  357578 MW;  85D459D79B4C8B27 CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKEKQQRQFQ LDTLEAALQK QKQKVENEKS
     EGTNLKRENQ RLMEICENLD KTKQKISHEL QVKESQVNFQ EGQLNSAKKQ IEKLEQEIKR
     CKSELERTQQ AAQSADVSLN PCNTPQKIYT TSLTPSHCYS GSKYEDLKEK YNKEVEERKR
     LEAEVKALQA KKMSQTLPQT TMNHRDIARH QASSSVFSWQ KERTPSHLSS NSQKTPVRRD
     FSTSYFSGEQ EMTPSQSALQ IGKRDTNSSF CDNSTSSHLL DQLKAQNQDL RSKINELELC
     LQGQEKEMKG QVNKFQETQL QLEKAKVELI DKEKILNKSR DELVRTAAQY DQASTKCTAL
     EQKLKKLTED LNCQRQNSES ARCSLEQKIK EKEKEFQEEL CRQQRSFQTL DQECTQMKAR
     LTQELQQAKN THNILQADLD KVTLVKQHLE NNLEEFKQKF CRAEQAFQAS QNKENELKRS
     VEEIKKENNL LKSQSEQKAR EVCHLEEELK KVKHCLNQSE NFAEEMKAKN TSQEAVLKGL
     EEKINQQENS LMLDKLKLVV ADLEKQRDCS QDLLKKREHH IEQLNDKLSK TEKESKALLS
     ALELKKKEYE ELKEEKTLFS CWKSENENLL SQMESEKESL QSKINHLESC LKMQQIKSHE
     YNERVRTLEI ERENLNVEIR NLHNIIDSKS VEIETQKQAY VALQQEAEFS DQKHKKEIEN
     MCLKTSQLTG QVEALEHKLQ LLSTEKIDKD QCYQDLHAEY ESLRALLKSK ESSLVTNENH
     QKSLLPFEQQ PDVNNSFLNI IREQENVPSE RSKCYLEADQ SSKNSTILQN RIDSLEFSLQ
     SQKQLNSDLQ KQCEELVQIR REIEENLIKA EQMHQSFVTE TSQRITKLQE DTSTHQNVVA
     ETLVSLENKE EELQLLKEKL ETEQAEIQEL KKSNHLLKDS LMELQVLCET LSSEKKEMGA
     VISLNKRQIE ELTQENETLK DINTTLNQEK MNLTQKSESF SHCVDGKEKS ISELSDQYKQ
     DRLTLLQKYE EARYAFEDLS EKYKAAQEKN STLEGLLNEC TSVSENRKNE LEQLKQTFAK
     EHQDLLTKLA FTEERNQTLI LQLGTVQQDL RSEIPDTQNN SKSKVDVLKQ DIMTLKEEQN
     KMEVNDLLQE NEPLMKLMKT KHECQNLELE PIRDYGKERE SEINKCNFQL QMNSYSAQLV
     QLEAMIRNME LKLQESEKEK EYLQHELQTV RAELETRSLQ GILSQEISGL KDYDMDAEEK
     YISVLHELST SQNDNAHLQC SLQTAKNKLN ELEKICEILK ADKCELMSEL NDSRSECITA
     TSRMAEEVEK LVNEVKILNH ENGLLHGDLV KEMPEGDFTE KQNEQQSVSL NPLDDSNSYE
     HLTLSHKEVQ RHFAELQEKF SSLQSEHKIL HDQHCQVSSK MSELQTYVNS LKAENLLLSA
     NLRNFQSDLM KETKLDSEEG QVPSPSFSCV PDSPSLTSFG ESSFYKALLE QTEETSLLNS
     LEGDVSKDEF YVDEMSNSSL EEESLTTKEI PSSSVRSVEE LETLCQMYLQ SLKNLEEKIE
     SQGIMKNKEI QELEQLLSTE RQALDCLRKQ YLSENEQWQQ KLTSVTMEME SKLAAEKKQT
     EQLSLELEVA RLQLQGLDLS SRSLLGTDIE DAIQNQNESC DVKESEGYTP ETIGQTPKND
     SHQICDKDVQ QELGLETREI RETDAVRLTE ECSREQSPEV GQEMSGEEKT PGSSECISEL
     SFSDPNSLGP MDFLVNQVTI QNLQLQVKKT SDENLRLLCV IKDRDKKVEN LLNEIKELDS
     KLVLQQVQMK TKIEACVELE KIVEELKKAN SDLSEKLESF SCDNLEVYQR IETCEVLNSN
     LGMGTDNLSF EHIEAKVNDN WKERFLGVEN ELNRIKSEKA SMEHHVLSVK ADLEIVQTEK
     LNLEKDNENK QKVIVSLEEE LSVVTSERNR LHGELDIVSK ENKELDRLSE MMKEKTQELE
     AHQGDCLHQM QVVEAEVKNK TEQLQTLSSD VSQLLKDKAH LQEQVHSLEK DSQALSLVKC
     ELEIQMRLLN KEKELLLKES ESLQAKLSES EHEKLNVCKA LEAALVEKGE FAERLSSTQE
     EVHQLRRGIE KLRVRIEADE KKQLHVAEKL KENELENDLL KDKVESLERE LQMSEENQEL
     VIVDAENLKA EIETLKSQVE EMAESLKVLE LDLDMVRSEK ENLTKELQEK QNQVLELDKL
     HSSYQSLLEK KEQVTIQIKE ASKTVAEMLQ NQLKELNEEV IALCNDQETW KSREQSLDSS
     VEEVQQLRSS IEKLKVCIEA DGKKQLHVLE QLKESKHHAD FLKGRAENLE RELEIVGKNQ
     EHVILEAENA KAEVETLKGK IEGMASNLRD LELDLVNIKS EKENLTKELQ KEQERVSELE
     ILNSSFENLL LEKEQELVHI KEETDTAIDM LHLQSNELNE KLANLCSDLE CYKTKEEKLS
     RQIDCLKLEK GQLALELDET RSNYITLQSS VNGLIQEVED GKYLQEKKDE EISRLKSQIQ
     DQEQLASRLF QVEGEQQLWK KEKVELGTLT VELEQKIQVL QSKNDTLQGT FETLQNSYKD
     MENELELAKM EKMSFVEKVN TMIAKETELQ REVHEMMQKT TEQKEDFGRE KNRLTEELNL
     LSEEIKNSKG QLKELVLENS ELKKSLDCIH KDQVEKDGKM REEIAEYQLQ LQEAEKKHQA
     LLSDTNKQHE IEIQTYQEKL MSKEEYLNSQ KLEMDLLKSS KEELNNSLKA TTQTLEELKK
     TKTDNLKYVN KLKKENEHAQ GKIKLLIKSC KQLEEEKEML QKKLSQLEAA QEKQKTDTVV
     DGKRDELISE MKELKETLEE KTREADEYLD KYCSLLISHE KLEKANEMLE TQVARLCSQQ
     SKLDLQRSPL LSPLASAPSP VPSLAEKKLS SGQNKASGKR QRSGGIWENS GGSAPPTPEV
     FSKRSRKAVK SGIQPAEDTE DIEFEPEGLP EVVKKGFADI PTGKTSPYIL RRTTMATRTS
     PRLAAQKLAL SPLSLGKENL AESSKPTAGG SRSQKVKIAQ HSPVDSGTAF QEPTTKTLSV
     NNLPERRSAD SPRESVRPKR GRLAPSLEAG AEPSKDGENC KVQ
//
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