ID H0WHX6_OTOGA Unreviewed; 3103 AA.
AC H0WHX6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 07-OCT-2020, entry version 52.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000001001};
GN Name=CENPF {ECO:0000313|Ensembl:ENSOGAP00000001001};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001001, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Ensembl:ENSOGAP00000001001, ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000001001}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2012) to UniProtKB.
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DR EMBL; AAQR03176577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003802097.1; XM_003802049.1.
DR STRING; 30611.ENSOGAP00000001001; -.
DR Ensembl; ENSOGAT00000001125; ENSOGAP00000001001; ENSOGAG00000001123.
DR GeneID; 100951736; -.
DR CTD; 1063; -.
DR eggNOG; ENOG502QVMD; Eukaryota.
DR GeneTree; ENSGT00730000111187; -.
DR HOGENOM; CLU_000551_0_0_1; -.
DR InParanoid; H0WHX6; -.
DR OMA; YNAQLVQ; -.
DR OrthoDB; 205405at2759; -.
DR TreeFam; TF101133; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 2.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 2.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 1..307
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 2119..2258
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2301..2440
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2957..3001
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 208..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1659..1682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1711..1738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2891..2967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3010..3103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 280..307
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 322..342
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 350..377
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 411..459
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 463..501
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 523..615
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 623..650
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 658..685
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 753..773
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 832..873
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 899..940
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 962..996
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1029..1088
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1118..1145
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1192..1233
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1275..1302
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1321..1341
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1386..1406
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1538..1590
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1613..1635
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1781..1843
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1878..1898
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1913..1947
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1958..1985
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1990..2031
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2046..2073
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2095..2122
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2130..2157
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2162..2220
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2224..2266
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2312..2339
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2347..2423
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2435..2469
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2505..2525
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2550..2598
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2617..2665
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2677..2704
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2706..2761
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2769..2817
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2824..2851
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2859..2879
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1659..1680
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2906..2930
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2943..2957
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3017..3066
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3067..3081
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3103 AA; 357578 MW; 85D459D79B4C8B27 CRC64;
MSWALEEWKE GLPTRALQKI QELEGQLDKL KKEKQQRQFQ LDTLEAALQK QKQKVENEKS
EGTNLKRENQ RLMEICENLD KTKQKISHEL QVKESQVNFQ EGQLNSAKKQ IEKLEQEIKR
CKSELERTQQ AAQSADVSLN PCNTPQKIYT TSLTPSHCYS GSKYEDLKEK YNKEVEERKR
LEAEVKALQA KKMSQTLPQT TMNHRDIARH QASSSVFSWQ KERTPSHLSS NSQKTPVRRD
FSTSYFSGEQ EMTPSQSALQ IGKRDTNSSF CDNSTSSHLL DQLKAQNQDL RSKINELELC
LQGQEKEMKG QVNKFQETQL QLEKAKVELI DKEKILNKSR DELVRTAAQY DQASTKCTAL
EQKLKKLTED LNCQRQNSES ARCSLEQKIK EKEKEFQEEL CRQQRSFQTL DQECTQMKAR
LTQELQQAKN THNILQADLD KVTLVKQHLE NNLEEFKQKF CRAEQAFQAS QNKENELKRS
VEEIKKENNL LKSQSEQKAR EVCHLEEELK KVKHCLNQSE NFAEEMKAKN TSQEAVLKGL
EEKINQQENS LMLDKLKLVV ADLEKQRDCS QDLLKKREHH IEQLNDKLSK TEKESKALLS
ALELKKKEYE ELKEEKTLFS CWKSENENLL SQMESEKESL QSKINHLESC LKMQQIKSHE
YNERVRTLEI ERENLNVEIR NLHNIIDSKS VEIETQKQAY VALQQEAEFS DQKHKKEIEN
MCLKTSQLTG QVEALEHKLQ LLSTEKIDKD QCYQDLHAEY ESLRALLKSK ESSLVTNENH
QKSLLPFEQQ PDVNNSFLNI IREQENVPSE RSKCYLEADQ SSKNSTILQN RIDSLEFSLQ
SQKQLNSDLQ KQCEELVQIR REIEENLIKA EQMHQSFVTE TSQRITKLQE DTSTHQNVVA
ETLVSLENKE EELQLLKEKL ETEQAEIQEL KKSNHLLKDS LMELQVLCET LSSEKKEMGA
VISLNKRQIE ELTQENETLK DINTTLNQEK MNLTQKSESF SHCVDGKEKS ISELSDQYKQ
DRLTLLQKYE EARYAFEDLS EKYKAAQEKN STLEGLLNEC TSVSENRKNE LEQLKQTFAK
EHQDLLTKLA FTEERNQTLI LQLGTVQQDL RSEIPDTQNN SKSKVDVLKQ DIMTLKEEQN
KMEVNDLLQE NEPLMKLMKT KHECQNLELE PIRDYGKERE SEINKCNFQL QMNSYSAQLV
QLEAMIRNME LKLQESEKEK EYLQHELQTV RAELETRSLQ GILSQEISGL KDYDMDAEEK
YISVLHELST SQNDNAHLQC SLQTAKNKLN ELEKICEILK ADKCELMSEL NDSRSECITA
TSRMAEEVEK LVNEVKILNH ENGLLHGDLV KEMPEGDFTE KQNEQQSVSL NPLDDSNSYE
HLTLSHKEVQ RHFAELQEKF SSLQSEHKIL HDQHCQVSSK MSELQTYVNS LKAENLLLSA
NLRNFQSDLM KETKLDSEEG QVPSPSFSCV PDSPSLTSFG ESSFYKALLE QTEETSLLNS
LEGDVSKDEF YVDEMSNSSL EEESLTTKEI PSSSVRSVEE LETLCQMYLQ SLKNLEEKIE
SQGIMKNKEI QELEQLLSTE RQALDCLRKQ YLSENEQWQQ KLTSVTMEME SKLAAEKKQT
EQLSLELEVA RLQLQGLDLS SRSLLGTDIE DAIQNQNESC DVKESEGYTP ETIGQTPKND
SHQICDKDVQ QELGLETREI RETDAVRLTE ECSREQSPEV GQEMSGEEKT PGSSECISEL
SFSDPNSLGP MDFLVNQVTI QNLQLQVKKT SDENLRLLCV IKDRDKKVEN LLNEIKELDS
KLVLQQVQMK TKIEACVELE KIVEELKKAN SDLSEKLESF SCDNLEVYQR IETCEVLNSN
LGMGTDNLSF EHIEAKVNDN WKERFLGVEN ELNRIKSEKA SMEHHVLSVK ADLEIVQTEK
LNLEKDNENK QKVIVSLEEE LSVVTSERNR LHGELDIVSK ENKELDRLSE MMKEKTQELE
AHQGDCLHQM QVVEAEVKNK TEQLQTLSSD VSQLLKDKAH LQEQVHSLEK DSQALSLVKC
ELEIQMRLLN KEKELLLKES ESLQAKLSES EHEKLNVCKA LEAALVEKGE FAERLSSTQE
EVHQLRRGIE KLRVRIEADE KKQLHVAEKL KENELENDLL KDKVESLERE LQMSEENQEL
VIVDAENLKA EIETLKSQVE EMAESLKVLE LDLDMVRSEK ENLTKELQEK QNQVLELDKL
HSSYQSLLEK KEQVTIQIKE ASKTVAEMLQ NQLKELNEEV IALCNDQETW KSREQSLDSS
VEEVQQLRSS IEKLKVCIEA DGKKQLHVLE QLKESKHHAD FLKGRAENLE RELEIVGKNQ
EHVILEAENA KAEVETLKGK IEGMASNLRD LELDLVNIKS EKENLTKELQ KEQERVSELE
ILNSSFENLL LEKEQELVHI KEETDTAIDM LHLQSNELNE KLANLCSDLE CYKTKEEKLS
RQIDCLKLEK GQLALELDET RSNYITLQSS VNGLIQEVED GKYLQEKKDE EISRLKSQIQ
DQEQLASRLF QVEGEQQLWK KEKVELGTLT VELEQKIQVL QSKNDTLQGT FETLQNSYKD
MENELELAKM EKMSFVEKVN TMIAKETELQ REVHEMMQKT TEQKEDFGRE KNRLTEELNL
LSEEIKNSKG QLKELVLENS ELKKSLDCIH KDQVEKDGKM REEIAEYQLQ LQEAEKKHQA
LLSDTNKQHE IEIQTYQEKL MSKEEYLNSQ KLEMDLLKSS KEELNNSLKA TTQTLEELKK
TKTDNLKYVN KLKKENEHAQ GKIKLLIKSC KQLEEEKEML QKKLSQLEAA QEKQKTDTVV
DGKRDELISE MKELKETLEE KTREADEYLD KYCSLLISHE KLEKANEMLE TQVARLCSQQ
SKLDLQRSPL LSPLASAPSP VPSLAEKKLS SGQNKASGKR QRSGGIWENS GGSAPPTPEV
FSKRSRKAVK SGIQPAEDTE DIEFEPEGLP EVVKKGFADI PTGKTSPYIL RRTTMATRTS
PRLAAQKLAL SPLSLGKENL AESSKPTAGG SRSQKVKIAQ HSPVDSGTAF QEPTTKTLSV
NNLPERRSAD SPRESVRPKR GRLAPSLEAG AEPSKDGENC KVQ
//
