ID H0WI57_OTOGA Unreviewed; 787 AA.
AC H0WI57;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=ADAM metallopeptidase domain 33 {ECO:0000313|Ensembl:ENSOGAP00000001095.2};
GN Name=ADAM33 {ECO:0000313|Ensembl:ENSOGAP00000001095.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001095.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000001095.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03053905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WI57; -.
DR STRING; 30611.ENSOGAP00000001095; -.
DR Ensembl; ENSOGAT00000001224.2; ENSOGAP00000001095.2; ENSOGAG00000001222.2.
DR eggNOG; KOG3607; Eukaryota.
DR GeneTree; ENSGT00940000158971; -.
DR HOGENOM; CLU_012714_7_2_1; -.
DR InParanoid; H0WI57; -.
DR OMA; MGAQCAH; -.
DR TreeFam; TF314733; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR002870; Peptidase_M12B_N.
DR InterPro; IPR034027; Reprolysin_adamalysin.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF38; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33; 1.
DR Pfam; PF08516; ADAM_CR; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF01562; Pep_M12B_propep; 1.
DR Pfam; PF01421; Reprolysin; 1.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..787
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003543899"
FT TRANSMEM 700..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 208..407
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 415..501
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT DOMAIN 647..679
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 182..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 344
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 343
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 347
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 353
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT DISULFID 473..493
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00068"
FT DISULFID 651..661
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 669..678
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 787 AA; 84461 MW; CB5A62500C082870 CRC64;
MVRGSRRARG SPVLLLLLLL WPALGVGLLQ GNSSGKSVTL HWVLDGQPRR TVTIEELVSN
PDSGLVALEA EGQELLLELE KNHRLLAPGY TETHYGPDGQ PVVLVPSHTD HCHYCGNVRG
FPSSWVVLST CSGMSGLIVL SSNASYYLHP RVPVDSKDFS THMIFLTEQL LTWKGGCGHR
DPGDKGGMAS LPRALQSRGR REPRRSQRYL ELYLVADHTL FLTQHQDLNR TKHRLLEVAS
YVDQILRTLD IQVVLSGLEV WTERDLCSIT PDANATLWAF LQWRRGLWAR RPHDSAQLLT
GCAFGGATVG LAPVEGMCRA ESSGGVSTDH SELAIGAAAT VAHEIGHSLG LSHDPDGCCV
EAKAEQGGCV MAAATGHPFP RVFSACSRRQ LRAFFRKGGG ACLSDAPEPG VLAPPARCGN
GFVEAGEECD CAPGQDCQDL CCFTHNCSLR VGAQCAHGDC CAHCLLKPAG ELCRQAAGEC
DLPEFCTGSS PTCPPDLYLL DGSPCAKGRG YCWDGACPTL EQQCQQLWGP GSRPAPEACF
QMVNSVGDAH GSCGQDSEGN FLPCAQRDAQ CGKLQCQGGE LSPLAPHTVP VDSTIHLDGS
EVTCQGVFAL PGAQLDLLNL GLVEPGTQCG PSMVCQDRRC QNTTSQELQH CLAACHNHGV
CNSNHNCHCA PGWAPPFCDK PGFGGSVDSS PTQSESHDTF LLAMLLSSLL PLLLGVGLAW
CYYRLPGVHL WRCPWGWRRH PTCTGPALGC SRDHSLGSVH STRLGPTATR EPWPLVPSHL
ESPLPHP
//
