ID H0WI65_OTOGA Unreviewed; 232 AA.
AC H0WI65;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=RNF125 {ECO:0000313|Ensembl:ENSOGAP00000001104.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001104.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000001104.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; AAQR03028575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03028576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03028577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03028578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03028579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003784807.1; XM_003784759.2.
DR AlphaFoldDB; H0WI65; -.
DR STRING; 30611.ENSOGAP00000001104; -.
DR Ensembl; ENSOGAT00000001234.2; ENSOGAP00000001104.2; ENSOGAG00000001232.2.
DR GeneID; 100948379; -.
DR KEGG; oga:100948379; -.
DR CTD; 54941; -.
DR eggNOG; ENOG502RYGV; Eukaryota.
DR GeneTree; ENSGT00950000182909; -.
DR HOGENOM; CLU_092448_2_0_1; -.
DR InParanoid; H0WI65; -.
DR OMA; QLRHTFY; -.
DR OrthoDB; 26661at2759; -.
DR TreeFam; TF331012; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; IEA:Ensembl.
DR GO; GO:0002039; F:p53 binding; IEA:Ensembl.
DR GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0039536; P:negative regulation of RIG-I signaling pathway; IEA:Ensembl.
DR GO; GO:0032480; P:negative regulation of type I interferon production; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd16542; RING-HC_RNF125; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR034734; ZF_C2HC_RNF.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR46016:SF2; E3 UBIQUITIN-PROTEIN LIGASE RNF125; 1.
DR PANTHER; PTHR46016; ZINC FINGER, RING/FYVE/PHD-TYPE; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR Pfam; PF05605; zf-Di19; 1.
DR Pfam; PF18574; zf_C2HC_14; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51803; ZF_C2HC_RNF; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 37..76
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 100..119
FT /note="C2HC RNF-type"
FT /evidence="ECO:0000259|PROSITE:PS51803"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 232 AA; 26452 MW; 640DC4BD9032219C CRC64;
MGSVLSSDSG KSAPASATPR ALERRRDPEL PVTSFDCSVC LEVLHQPVRT RCGHVFCRSC
IATSLKNNKW TCPYCRAYLP SEGVPATDVA KRMKSEYQNC AECDTMVCLS DMRAHIRTCQ
KYIDKYGPLQ ELGETATRCV CPFCQRELDE DSLLDHCITH HRSERRPVFC PLCRLIPNEN
PSTFNGSLIR HLQDSHTLFY DDFLDFNIIE EALIRRVLDR SLLEYVNHSN TT
//
