ID H0WIA3_OTOGA Unreviewed; 419 AA.
AC H0WIA3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Zinc finger protein 566 {ECO:0000313|Ensembl:ENSOGAP00000001148.2};
GN Name=ZNF566 {ECO:0000313|Ensembl:ENSOGAP00000001148.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001148.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000001148.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AAQR03125306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03125307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WIA3; -.
DR STRING; 30611.ENSOGAP00000001148; -.
DR Ensembl; ENSOGAT00000001287.2; ENSOGAP00000001148.2; ENSOGAG00000001286.2.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162125; -.
DR HOGENOM; CLU_002678_0_9_1; -.
DR InParanoid; H0WIA3; -.
DR OMA; IMGRLTR; -.
DR TreeFam; TF338743; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF138; ZINC FINGER PROTEIN 589; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 6..78
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 200..227
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 228..255
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 256..283
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 284..311
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 312..339
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 340..367
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 368..395
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 419 AA; 49211 MW; 9AD68A54E6431D43 CRC64;
LFQESVMFSD VSIDFSQEEW ECLNDDQRDL YRDVMLENYS NLVSMAGHSI SKPNVISYLE
QGKEPWLVDR ELTRGQWPVL ESKCGTKKFF LKKEIYEIES AQWNIMEKLT RHDLQCSSFQ
DDWECSGQFE KQHGSQEGQF SQMILTHEDL PTFSQHPSFT LQQIINNKDK YCTAKEYRKT
FRHGSQFTTR QIIHTIEKPY ECKDCGKSFR HPSRLAHHQK IHTGKKPFEC KECGKTFICG
SDLTRHHRIH TGEKPYECKE CGKAFSSGSN FTRHQRIHTG EKPYECKECG KAFSSGSNFT
QHQRIHTGEK PYECKECGNA FSQSSQLIKH QRIHTGEKPY ECKECEKAFR SGSDLTRHQR
IHTGEKPYEC KICGKAYSQS SQLISHHRIH TGEKPYEYRE CGKNFNYESQ FIQHQNLYW
//
