ID H0WII6_OTOGA Unreviewed; 903 AA.
AC H0WII6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Schlafen family member 11 {ECO:0008006|Google:ProtNLM};
GN Name=SLFN11 {ECO:0000313|Ensembl:ENSOGAP00000001251.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001251.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000001251.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Schlafen family. Subgroup III subfamily.
CC {ECO:0000256|ARBA:ARBA00010114}.
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DR EMBL; AAQR03133447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WII6; -.
DR STRING; 30611.ENSOGAP00000001251; -.
DR Ensembl; ENSOGAT00000001407.2; ENSOGAP00000001251.2; ENSOGAG00000001405.2.
DR eggNOG; ENOG502QWKG; Eukaryota.
DR GeneTree; ENSGT00410000025651; -.
DR HOGENOM; CLU_007071_0_0_1; -.
DR InParanoid; H0WII6; -.
DR OMA; HKLCVIP; -.
DR TreeFam; TF337168; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.950.30; Schlafen, AAA domain; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031450; Poxin-SLFN/SLFN_N.
DR InterPro; IPR029684; Schlafen.
DR InterPro; IPR007421; Schlafen_AlbA_2_dom.
DR InterPro; IPR038461; Schlafen_AlbA_2_dom_sf.
DR InterPro; IPR018647; SLFN_3-like_DNA/RNA_helicase.
DR InterPro; IPR048729; SLFN_GTPase-like.
DR PANTHER; PTHR12155; SCHLAFEN; 1.
DR PANTHER; PTHR12155:SF43; SCHLAFEN FAMILY MEMBER 13; 1.
DR Pfam; PF17057; B3R; 1.
DR Pfam; PF09848; SLFN-g3_helicase; 1.
DR Pfam; PF04326; SLFN_AlbA_2; 1.
DR Pfam; PF21026; SLFN_GTPase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 93..206
FT /note="Poxin-Schlafen/Schlafen-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17057"
FT DOMAIN 208..323
FT /note="Schlafen AlbA-2"
FT /evidence="ECO:0000259|Pfam:PF04326"
FT DOMAIN 407..543
FT /note="Schlafen GTPase-like"
FT /evidence="ECO:0000259|Pfam:PF21026"
FT DOMAIN 598..756
FT /note="Schlafen group 3-like DNA/RNA helicase"
FT /evidence="ECO:0000259|Pfam:PF09848"
SQ SEQUENCE 903 AA; 102821 MW; ED573950C3D3E288 CRC64;
MKKNHCSLVL EPPCSDLVID VGEVTLGERN RNELQKTQRE QEKARVVQAA CALLNSGGGV
IRMEMKNKDE HPVEMGQDLE LALRELIQSS DFQAFFEYNP QGRNFYIFVK SWSSDSFSED
TSVKPRICSL SSSLYCRSGT CVLAMDSRKA FGFLMTKKKD AKYRLNNEGS PPSKIPQIDH
QNTSESNPAY RIFQMNRLTY GEILPFPESQ CIEFKQFSTK NMPKYIKNLI PQYISAFANT
RGGYLFIGVD DESKKVLGCA KENVDLKSLK DIIAGTISKL PLVHFCSSQP MVEYSIKIID
VFKGEELYGY LCVIKVEPFC CAVFSEDPKS WIVNNKKICS LTAKKWGDMM IDTDPELISE
LAEAFESQLS LSHGPPLCRP VYSKKGLEHK ADLQQRLFPA HPVPSDHLRY TPESLWQELV
SEHEGLEELI HRQMRPFSQG ILIFSRSWAV DLNLQEKEGV LCDALLIAQN SPPILYTILG
EQETGGQDYC TSTVFTLKQK LVNLGGYTGK LCVMAKVLRL RAESNTDSLG GEVSLIDYPR
SYSFLGTQQA EALLQALVIV LLSFRSLLSD QLGCEVLNLL TAQQYELFSK NLRKNRELFV
HGLPGSGKTI MAMKITEKIR NVFHCDPREI LYVCENQPLR DTIRKMKICK AVTRKTFIKS
IFKFKLIQHI IIDEAQNFRK ENGDWYKKAK AITQRKKACP GILWIFLDYF QTSHLSQSGL
PLLSEQYPRE ELTKVVRNAD EIANYLQEII QKIREHPPPN LPPEYLVMLH EAEWAPGVTG
SKTIKNLNLE QMVTYIANEC HRLLRNGYSP KDIAILCSTE SEVNKYKDKI LKEMKKRKFS
QINDVSIFTE DMVDSVRRFS GLERNIVFGI NPTTAETAIY NNFLLCLASR ANKHLYILSL
SNS
//
