ID H0WJ14_OTOGA Unreviewed; 1236 AA.
AC H0WJ14;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Alpha kinase 1 {ECO:0000313|Ensembl:ENSOGAP00000001457.2};
GN Name=ALPK1 {ECO:0000313|Ensembl:ENSOGAP00000001457.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001457.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000001457.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03142092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03142093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03142094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03142095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03142096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WJ14; -.
DR STRING; 30611.ENSOGAP00000001457; -.
DR Ensembl; ENSOGAT00000001635.2; ENSOGAP00000001457.2; ENSOGAG00000001634.2.
DR eggNOG; ENOG502QX1X; Eukaryota.
DR GeneTree; ENSGT00940000159753; -.
DR HOGENOM; CLU_007421_0_0_1; -.
DR InParanoid; H0WJ14; -.
DR OMA; KCNEICH; -.
DR TreeFam; TF316085; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005929; C:cilium; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0048029; F:monosaccharide binding; IEA:Ensembl.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0002753; P:cytoplasmic pattern recognition receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR CDD; cd16969; Alpha_kinase_ALPK1; 1.
DR Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR InterPro; IPR004166; a-kinase_dom.
DR InterPro; IPR043529; ALPK1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR46747; ALPHA-PROTEIN KINASE 1; 1.
DR PANTHER; PTHR46747:SF1; ALPHA-PROTEIN KINASE 1; 1.
DR Pfam; PF02816; Alpha_kinase; 1.
DR SMART; SM00811; Alpha_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51158; ALPHA_KINASE; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1011..1231
FT /note="Alpha-type protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS51158"
FT REGION 504..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..769
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1236 AA; 137087 MW; 4B9417C45F37C5D3 CRC64;
MNNQKAVGAL LQECKQVLDQ LLLETPDVSE EDMSEDQRCR ASLPSELRTL IEEAKEMKWP
FVPEKWQYKQ AVGPEDKTNL QDVIGAGLQQ LLASLRASIR ARDCGAAAAV VFLVDRFLYG
LDVSGELLRV AKGLHKLQPA TPIAPQVVIR QARLSVTQGK LLKAEYILSS LISNNGATGS
WLYRNESDKV LVQSVCVQIR GQILQKLGMW YEAAELIWAS IVGYLTLPQP DKKGISTSLG
ILADIFVSMS KKDYGKFKDS PQINLGLLRE FDHQLLAAAE ACKLAAAFSA YTPLFVLTAV
NIRGTCLLSY SSSNDCPPGM KNLYLCEAKE AFEIGLLTKR DDEPVTGKQE LHSFVKAAFG
LTTVHRRLHG ETGTICAAGQ LCKEAMEKLY TFSTSSRSQD REALSQEIMS VIAQVKDHLQ
VQNFSNLEER SYVPESFKCG LDKPFLHGQV DFQKILETYS QHHTSVCEVF ESSCGDNKNK
QKDIKTGVCI TALKTETKNI DTMTTTQDKP LSQKSMGISS SHLARNSQEK LRRVERRNWT
HSDAFRVSLD QDAESETEPP DPSSGGGAIL NKSLSDSQTS SSWSKLSGFS SSTSWEEVNY
PVDGRSTRKE PSKEEHLVDT QCSTALSEEL EKDGDGRAVP LCSELHGLSL QGDNVESSQS
QLNKHMPLTT FSSHNTADTL LASDAGLLEG ALADVQEVRN SGPRNNSAHS RLSRGSASWS
SSGSGRLKKM VTYPSFQEET FEIIDEVPET NCDAKERSRE EKGEEINEKG TGPISKNSPN
WVDPEGETAE GTEDAPLDFP GETDNYLGNS SMMACSSFTP VENPDSGKSG GSLTYQDIDP
DAPTEDEKGQ VLNSTDVHST GGYGSHRPCT LRQPPGQRAE TPHSSVSNNV LVPVLGEDCT
TTEEGNEPGN VLNCSQNSSS SSAWWMKSPA FSSGSSEGES PWSCLNSSAS SFVSLPGKTR
QEILEARTLQ PDDFEKLLAG VSHDWLFQRL ENTGVFKPSQ LHRAHTALLL KYSKTSDLWT
AQETTVYLGN YLNVKKKGRQ RNAFWVHHLH QEEILGRYVG KEYKEQKGLW HHFTDVERQM
TAQYYVTEFN KRLYEQNIST QIFYIPSTIL LILEGKTIKG CISVEPYILG EFVKLSNNTK
VVKTEYKATE YGLAYGHFSY EFSNHRDVVV DLQGWVTGNG KGLIYLTDPQ IHSVDQKDVT
TNFGKRGIFY FFNNQHMKCN EICHRLSLTR PSIKKP
//
