ID H0WJ26_OTOGA Unreviewed; 378 AA.
AC H0WJ26;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=C-C motif chemokine receptor 7 {ECO:0000313|Ensembl:ENSOGAP00000001472.2};
GN Name=CCR7 {ECO:0000313|Ensembl:ENSOGAP00000001472.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001472.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000001472.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AAQR03042910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003786438.1; XM_003786390.2.
DR AlphaFoldDB; H0WJ26; -.
DR STRING; 30611.ENSOGAP00000001472; -.
DR Ensembl; ENSOGAT00000001651.2; ENSOGAP00000001472.2; ENSOGAG00000001650.2.
DR GeneID; 100946487; -.
DR KEGG; oga:100946487; -.
DR CTD; 1236; -.
DR eggNOG; ENOG502QUZ9; Eukaryota.
DR GeneTree; ENSGT01030000234667; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; H0WJ26; -.
DR OMA; TLACFRC; -.
DR OrthoDB; 5358146at2759; -.
DR TreeFam; TF330966; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0038117; F:C-C motif chemokine 19 receptor activity; IEA:Ensembl.
DR GO; GO:0038121; F:C-C motif chemokine 21 receptor activity; IEA:Ensembl.
DR GO; GO:0035757; F:chemokine (C-C motif) ligand 19 binding; IEA:Ensembl.
DR GO; GO:0035758; F:chemokine (C-C motif) ligand 21 binding; IEA:Ensembl.
DR GO; GO:0048872; P:homeostasis of number of cells; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0097029; P:mature conventional dendritic cell differentiation; IEA:Ensembl.
DR GO; GO:0002408; P:myeloid dendritic cell chemotaxis; IEA:Ensembl.
DR GO; GO:0032695; P:negative regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0045060; P:negative thymic T cell selection; IEA:Ensembl.
DR GO; GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; IEA:Ensembl.
DR GO; GO:2000510; P:positive regulation of dendritic cell chemotaxis; IEA:Ensembl.
DR GO; GO:2000526; P:positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation; IEA:Ensembl.
DR GO; GO:0002922; P:positive regulation of humoral immune response; IEA:Ensembl.
DR GO; GO:0002885; P:positive regulation of hypersensitivity; IEA:Ensembl.
DR GO; GO:2000522; P:positive regulation of immunological synapse formation; IEA:Ensembl.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IEA:Ensembl.
DR GO; GO:2000525; P:positive regulation of T cell costimulation; IEA:Ensembl.
DR GO; GO:0050862; P:positive regulation of T cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0032651; P:regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0032649; P:regulation of type II interferon production; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR CDD; cd15175; 7tmA_CCR7; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001718; Chemokine_CCR7.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF635; C-C CHEMOKINE RECEPTOR TYPE 7; 1.
DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR00641; CHEMOKINER7.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..378
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003543584"
FT TRANSMEM 59..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 75..326
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 378 AA; 42775 MW; 0C247DF2CE44DC78 CRC64;
MDLGKPMKSV LVVALLVVFQ VCLCQDEVTD DYIGDNTTVD YTLWESLCFK KDVRNFKAWF
LPIMYSVICI VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL AMADILSLLT LPFWAYSAAK
SWVFGVHFCK LIFGIYKISF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCA
GIWMLAMVLS TPELLYSGIQ KTNSEQTLRC SLISEHVEAF IIVHVAQMVI GFLVPLLAMS
FCYLVIILTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVILAKTMAN FNITSGSCEH
SKQLDIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE QLRQWSSCRH
ARRTSMSVEA ETTTTFSP
//
