ID H0WK44_OTOGA Unreviewed; 611 AA.
AC H0WK44;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Zinc finger protein 496 {ECO:0000313|Ensembl:ENSOGAP00000001914.2};
GN Name=ZNF496 {ECO:0000313|Ensembl:ENSOGAP00000001914.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001914.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000001914.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00187}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03186396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03186397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03186398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03186399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03186400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03186401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03186402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03186403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03186404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WK44; -.
DR STRING; 30611.ENSOGAP00000001914; -.
DR Ensembl; ENSOGAT00000002142.2; ENSOGAP00000001914.2; ENSOGAG00000002139.2.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161967; -.
DR HOGENOM; CLU_002678_49_8_1; -.
DR InParanoid; H0WK44; -.
DR OMA; AFRWRVN; -.
DR TreeFam; TF336839; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45935; PROTEIN ZBED8-RELATED; 1.
DR PANTHER; PTHR45935:SF15; SCAN DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 42..123
FT /note="SCAN box"
FT /evidence="ECO:0000259|PROSITE:PS50804"
FT DOMAIN 436..464
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 465..492
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 493..520
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 546..574
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 577..604
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 69681 MW; 993BDDB500E144B8 CRC64;
MPTALCPRVL APKESEEPRK MRSPPGENTS PQGELPSPES SRRLFRRFRY QEAAGPREAL
HRLWDLCRGW LRPERHTKEQ ILELLVLEQF LAILPREIQS WVRAQEPESG EQAVAAVETL
EREPGRPWQW LKHCEDPVVI DDGDSTLDQE QEQLPEESQS DLAKSQDAQS MALAQGLGLP
SRPPGQLNGD PVLQDAFLLQ EETVRDAQQV ATLQLPPDIF KFNNHHIMVE CEDCLSPGVQ
DCRLMMPLHS SLSNRVRPCF KNKNHCIYYF RNVSKWKEGI TGNFSTITEP CNDPVTQPDL
SLGEENEPRV PELQDLQGKE APQVSYLDFP SSQPFQVEEK RRRDEPQVPE FQACQQTALA
QSTCPAGGDP PSLERSLNEE VTIEIVLSSS GDEDSQHGPY CTEEPGSPAE TQRSLRASHR
SSAEAGGDGQ TSKKSYVCPN CGKIFRWRVN FIRHLRSRRE REKPHECSVC GEMFSDSEDL
DGHLETHEAQ KPYRCGACGK SFRLNSHLLS HRRIHLQPDR PEQGASEDAG EEPGDTQEKS
ESELGYQCCD CGKGFQRHDQ LVRHRSHFHP KDKARPFQCR YCVKSFKQNY DLLRHERLHM
KRRSKQALNS Y
//
