ID H0WKA5_OTOGA Unreviewed; 1092 AA.
AC H0WKA5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Leucine rich repeats and immunoglobulin like domains 1 {ECO:0000313|Ensembl:ENSOGAP00000001986.2};
GN Name=LRIG1 {ECO:0000313|Ensembl:ENSOGAP00000001986.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001986.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000001986.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03036741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03036742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03036743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WKA5; -.
DR STRING; 30611.ENSOGAP00000001986; -.
DR Ensembl; ENSOGAT00000002224.2; ENSOGAP00000001986.2; ENSOGAG00000002220.2.
DR eggNOG; KOG4194; Eukaryota.
DR GeneTree; ENSGT00940000158502; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; H0WKA5; -.
DR OMA; HDTIERS; -.
DR TreeFam; TF325380; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05763; IgI_LRIG1-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45842:SF12; KEKKON 5, ISOFORM A; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01463; LRRCT; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS51450; LRR; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..1092
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003544648"
FT TRANSMEM 794..817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 496..595
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 600..689
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 694..780
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 898..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1092 AA; 119138 MW; 1B6507E9B01036CA CRC64;
MARRVPGALR APRCSSRLLL WLLLLLWLEP ATAVAGPRAP CAAACTCAGD SLDCGGRGLV
ALPGDLPSWT RSLNLSYNKF SEIDPAGFED LPNLQEVYLS NNELTAIPSL GAASTHVVSL
FLQHLVSSLL GRRPVTVVSL DDCLSLNNVY FLRSICCSGF PHGSLSLWAN LASNRIGTLE
SGAFDGLSRS LLTLRLSKNR ITQLPVKAFK LPRLTQLDLN RNRIRLIEGL TFQGLDSLEV
LKLQRNNISK LTDGAFWGLS KMHVLHLEYN SLLEVNSGSL YGLTALHQLH LSNNSISRIH
RDGWSFCQKL HELVLSFNNL TRLDEESLAE LSSLSVLRLS HNAISHIAEG AFKGLKNLRV
LDLDHNEISG TIEDTSGAFT GLDSLSKLNL FGNKIKSVAK RAFSGLEGLE HLNLGENAIR
SVQFDAFVKM KNLKELHISS DSFLCDCQLK WLPLWLTSRM LQAFVTATCA HPESLKGHSI
FLVLPESFVC DDFPKPQIIT QPETTVAVVG KDIRFTCSAA SSSSSPMTFA WKKDNEVLTN
ADMENFAHVR AQDGEVMEYT TILHLRQVTF GHEGRYQCVI TNHFGSTYSH KARLTVNVLP
SFTKMPHDIA IRTGTMARLE CAATGHPNPQ IAWQKDGGTD FPAARERRMH VMPDDDVFFI
TDVKIDDMGV YSCTAQNSAG SISANATLTV LETPSLAVPL EDRVVSVGET VALQCKATGS
PLPRITWFKG DRPLSLTERH HFTPGNQLLV VQNVVAEDAG RYTCEMSNTL GTERAHSQLS
ILPTPGCRKD GTTVGIFTIA VVCSIVLTSL VWVCIIYQTR RKSEEYSVTN TDETIVPPDV
PSYLSSQGTL SDRQETVVRP EGGHQANGHI ESNGVCPRDV GLFPEADGPG IPCRQPKLCA
GHNKEPRKVT EKANGTPVPR KMEPSGPMVC SDCSADVDGY SKEQALYAQP VSRDTTQPST
LGVQEPSQND QEHSPYHQSS GTGDGSYTNY RGSLYPSNHD RMLTALKKKP VASPDGKGDP
SRTLARLYEP DSTDLQPASL SSGSPTIPSE AQHLLVSNGC LPKAFDSDPK STTLTGQLAG
KQKVPLLLAS KS
//
