ID H0WKT1_OTOGA Unreviewed; 636 AA.
AC H0WKT1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=SH3 domain containing kinase binding protein 1 {ECO:0000313|Ensembl:ENSOGAP00000002209.2};
GN Name=SH3KBP1 {ECO:0000313|Ensembl:ENSOGAP00000002209.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000002209.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000002209.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03085521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03085522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03085523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03085524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03085525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03085526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03085527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03085528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03085529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03085530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WKT1; -.
DR STRING; 30611.ENSOGAP00000002209; -.
DR Ensembl; ENSOGAT00000002472.2; ENSOGAP00000002209.2; ENSOGAG00000002469.2.
DR eggNOG; KOG4348; Eukaryota.
DR GeneTree; ENSGT00940000155886; -.
DR HOGENOM; CLU_024255_1_0_1; -.
DR InParanoid; H0WKT1; -.
DR OMA; EPNEMQP; -.
DR TreeFam; TF350191; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0050871; P:positive regulation of B cell activation; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR CDD; cd12055; SH3_CIN85_2; 1.
DR CDD; cd12057; SH3_CIN85_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035771; CIN85_SH3_2.
DR InterPro; IPR035772; CIN85_SH3_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14167:SF6; SH3 DOMAIN-CONTAINING KINASE-BINDING PROTEIN 1; 1.
DR Pfam; PF14604; SH3_9; 2.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 25..84
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 238..299
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 148..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 69605 MW; E389469D63953BD5 CRC64;
MHEVSSGNSL LSSETILRTN KRGERRRRRC QVAFSYLPQN DDELELKVGD IIEVVGEVEE
GWWEGVLNGK TGMFPSNFIK ELSGESDELS VCQDEQLSKS RPEGLPPASL LPFPAHGAKG
KTTFEGTILY RAAPGKTEGH RRYYSLRETT GSESDGGDSS STKSEGANGT VATAAIQPKK
VKGVGFGDIF KDKPIKLRPR SIEVENDFLA VDKTIGKKLP PTTATPDSSK TEMDSRTKTK
DYCKVMFPYE AQNDDELTIK EGDIVTLINK DCIDAGWWEG ELNGRRGVFP DNFVKLLPPD
FEKEGNRPKK PPPPSAPVIK QGAGTTERKH EIKKVPPERP ETLPNRTEEK ERPEREPKLD
LQKPSVPAIP PKKPRPPKTN SLNRPGALPP RRPERPVGPL THTRGDGPKI DLAGSSLSSI
LDKDLSDRSN DIDLEGFDSV VSSTEKLSHP TTSRPKATGR RPPSQSLTSS SLSSPDIFDS
PSPEEDKEEH ISLAHRGVDA SKKTSKTVTI SQVSDNKASL PPKPGTMAAG SSGPASLSSA
APSSLSSSLG TVGHRANSPS LFSMEGKPKM EPAASSQAAV EELRTQVREL RSIIETMKDQ
QKREIKQLLS ELDEEKKIRL RLQMEVNDIK KALQSK
//
