ID H0WLK8_OTOGA Unreviewed; 749 AA.
AC H0WLK8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Aconitase 2 {ECO:0000313|Ensembl:ENSOGAP00000002549.2};
GN Name=ACO2 {ECO:0000313|Ensembl:ENSOGAP00000002549.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000002549.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000002549.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC {ECO:0000256|ARBA:ARBA00007185}.
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DR EMBL; AAQR03015953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03015954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03015955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03015956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03015957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WLK8; -.
DR STRING; 30611.ENSOGAP00000002549; -.
DR Ensembl; ENSOGAT00000002849.2; ENSOGAP00000002549.2; ENSOGAG00000002845.2.
DR eggNOG; KOG0453; Eukaryota.
DR GeneTree; ENSGT00940000154892; -.
DR HOGENOM; CLU_006714_2_2_1; -.
DR InParanoid; H0WLK8; -.
DR OMA; NTHAFVA; -.
DR TreeFam; TF300627; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003994; F:aconitate hydratase activity; IEA:Ensembl.
DR GO; GO:0005506; F:iron ion binding; IEA:Ensembl.
DR GO; GO:0006101; P:citrate metabolic process; IEA:Ensembl.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:Ensembl.
DR CDD; cd01578; AcnA_Mitochon_Swivel; 1.
DR CDD; cd01584; AcnA_Mitochondrial; 1.
DR Gene3D; 3.40.1060.10; Aconitase, Domain 2; 2.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR015932; Aconitase_dom2.
DR InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR PANTHER; PTHR43160; ACONITATE HYDRATASE B; 1.
DR PANTHER; PTHR43160:SF3; ACONITATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF00330; Aconitase; 2.
DR Pfam; PF00694; Aconitase_C; 1.
DR PRINTS; PR00415; ACONITASE.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR PROSITE; PS00450; ACONITASE_1; 1.
DR PROSITE; PS01244; ACONITASE_2; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 10..222
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 248..472
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 552..680
FT /note="Aconitase A/isopropylmalate dehydratase small
FT subunit swivel"
FT /evidence="ECO:0000259|Pfam:PF00694"
FT REGION 500..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 81727 MW; 32E46F20F99E4AE3 CRC64;
RLNRPLTLSE KIVYGHLDDP ANQEVERGKT YLRLRPDRVA MQDATAQMAM LQFISSGLPK
VAVPSTIHCD HLIEAQLGGD KDLRRAKDIN QEVYNFLATA GAKYGVGFWR PGSGIIHQII
LENYAYPGVL LIGTDSHTPN GGGLGGICIG VGGADAVDVM AGIPWELKCP KVIGVKLTGS
LSGWSSPKDV ILKVAGILTV KGGTGAIVEY HGPGVDSISC TGEKGGHVMW SSPCAWPDGT
CINLRDCMAT ICNMGAEIGA TTSVFPYNHR MKKYLSKTGR AEIARLADEF KDHLVPDPGC
HYDQLIEINL NEVRKVIGRA CGPLVSHQPC ILLPESSWSG GWEIHLRLGL IGSCTNSSYE
DMGRSAAVAK QALAHGLKCK SQFTITPGSE QIRATIERDG YAQILRDVGG IVLANACGPC
IGQWDRKDIK KGEKNTIVTS YNRNFTGRND ANPETHAFVT SPEIVTALAI AGTLKFNPET
DFLTGKDGKK FKLEAPDADE LPHAEFDPGQ DTYQQPPKDG SGLRVDVSPT SQRLQLLEPF
DKWDGKDLED LQILIKVKGK CTTDHISAAG PWLKFRGHLD NISNNLLIGA INIENGKANS
IRNAVTQEFG PVPDTARYYK KHGIRWVVIG DENYGEGSSR EHAALEPRHL GGRAIITKSF
ARIHETNLKK QGLLPLTFAD PADYNKIHPV DKLTIQGLKD FAPGKPLKCI IKHPNGTQET
ILLNHTFNET QIEWFRAGSA LNRMKELQQ
//