ID H0WLR8_OTOGA Unreviewed; 995 AA.
AC H0WLR8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 3 {ECO:0000313|Ensembl:ENSOGAP00000002624.2};
GN Name=SCUBE3 {ECO:0000313|Ensembl:ENSOGAP00000002624.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000002624.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000002624.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AAQR03060511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03060512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03060513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03060514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WLR8; -.
DR STRING; 30611.ENSOGAP00000002624; -.
DR Ensembl; ENSOGAT00000002935.2; ENSOGAP00000002624.2; ENSOGAG00000002933.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000153185; -.
DR HOGENOM; CLU_013079_0_0_1; -.
DR InParanoid; H0WLR8; -.
DR OMA; TCALSCP; -.
DR TreeFam; TF351672; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0036122; F:BMP binding; IEA:Ensembl.
DR GO; GO:0070700; F:BMP receptor binding; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF2; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..995
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003543630"
FT DOMAIN 29..69
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 114..150
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 279..319
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 320..358
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 359..400
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 806..918
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 324..334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 995 AA; 109506 MW; 7C690178D3EF3960 CRC64;
MGSGRVPGLC LFVLLVHARA AQHSKAAQDV DECVEGTDNC HIDAICQNTP RSYKCICKSG
YTGDGKHCKA TDVDECERED NAGCVHDCVN IPGNYRCTCY DGFHLAHDGH NCLDVDECAE
GNGGCQQSCV NMMGSYECHC REGFFLSDNQ HTCIQRPEEG MNCMNKNHGC AHICRETPKG
GIACECRPGF ELTKNQRDCK LTCNYGNGGC QHTCDDTEQG PRCGCHVKFV LHTDGKTCIE
TCAVNNGGCD SKCHDAATGV HCSCPVGFML QPDRKTCKDI DECRLNNGGC DHICRNTVGS
FECSCKKGYK LLINERNCQD IDECSFDRTC DHICVNTPGS FQCLCHRGYL LYGVTHCGDV
DECSINRGGC RFGCINTPGS YQCTCPAGQG RLHWNGKDCT EPVKCQGSPG ALKAMLSCNR
SGKKDTCALT CPSRARFSPE SENGFTVSCG IPSPRAAPPR ASHTGNNTSS NHCHEAAVLS
IKQRASFKIK DAKCRLHLRN KGKMEEAGKI PGPGGTPCSD CHVTFIHLKC DSSRKGKGRR
ARTPPGKEVT RLTLELEAEV RTEETTAACG LPCLRQRMER RLKGSLKMLR KSINQDRFLL
RLAGLDYELA HKPGLVAGER TELVESCRPG QHRAGAKCVS CPQGTYYHGQ TEQCVPCPAG
TFQEREGQLS CDLCPGSDAH GPLGATNVTT CAGQCPPGHH SVDGFKPCQP CPRGTYQPEA
GRTLCFPCGG GLTTKHEGAI SFQDCDTKVQ CSPGHYYNTS IHRCIRCAMG SYQPDFRQNF
CTRCPGNTST DFDGSTSVAQ CKNRQCGGEL GEFTGYIESP NYPGNYPAGV ECIWNINPPP
KRKILIVVPE IFLPSEDECG DVLVMRKNSS PSSITTYETC QTYERPIAFT ARSRKLWINF
KTSEANSARG FQIPYVTYDE DYEQLVEDIV RDGRLYASEN HQEILKDKKL IKAFFEVLAH
PQNYFKYTEK HKEMLPKSFI KLLRSKVSSF LRPYK
//
