ID H0WM19_OTOGA Unreviewed; 561 AA.
AC H0WM19;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Adhesion G protein-coupled receptor A1 {ECO:0000313|Ensembl:ENSOGAP00000002742.2};
GN Name=ADGRA1 {ECO:0000313|Ensembl:ENSOGAP00000002742.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000002742.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000002742.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAQR03106475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03106476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03106477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03106478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WM19; -.
DR STRING; 30611.ENSOGAP00000002742; -.
DR Ensembl; ENSOGAT00000003064.2; ENSOGAP00000002742.2; ENSOGAG00000003060.2.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160175; -.
DR HOGENOM; CLU_020720_0_0_1; -.
DR InParanoid; H0WM19; -.
DR OMA; AHIHVHE; -.
DR TreeFam; TF331206; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR PANTHER; PTHR45930:SF3; ADHESION G PROTEIN-COUPLED RECEPTOR A1; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transducer {ECO:0000256|ARBA:ARBA00023040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 82..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..314
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 444..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 561 AA; 61552 MW; 8FFEDC1E249F84F7 CRC64;
AVGWDLKTVL SLPQYPGEFL HPVVYACTAV MLLCLLASAV TYIVHQSAIR ISRKGRHMLL
NFCFHAALTF TVFAGGINRT QYPILCQAVG IALHYSTLAT MLWIGVTARN IYQQVTKKAP
PCTNGDQPRL PRQRLLRFYL VSGGVPFIIC GVTAATNIRN YGTEDEDTAY CWMAWEPSLG
AFYGPAAFIA LVTCVYLLGT YVQLRRHPER RYELRARTEE TQRLAGPEGG LRVARPCSPP
ARDVPAASLL QNEHSLQAQL RAAAFTLFLF AATWAFGALA VSQGHFLDMV FSCLYGAFCV
TLGLFVLIHH CAKREDVWRC WWACCPSRTD GPAAEPGTRA ALHANGDAPC LGQLRGFSHT
PGHCKMTNLQ AAQGHVSCLS PATPCCAQMH CEQLMEEEAH SHLHEEDAFR HDPHLHRCLK
GRTKPHYFSR PRTSTELEYA YHIPSSLDGS PHSSRTDSPS SSLEVPAGAH ALACCAQGDP
FPLVSQPESD SAVLYGCPSR LGREAALGPG HLEMLRRTQS LPFGSPGQNG LLQGDLQECL
PFGTDRTGNI RTGPWKNETT V
//
