ID H0WMD2_OTOGA Unreviewed; 537 AA.
AC H0WMD2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Leucine rich repeat LGI family member 4 {ECO:0000313|Ensembl:ENSOGAP00000002889.2};
GN Name=LGI4 {ECO:0000313|Ensembl:ENSOGAP00000002889.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000002889.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000002889.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AAQR03125215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003796142.1; XM_003796094.2.
DR AlphaFoldDB; H0WMD2; -.
DR STRING; 30611.ENSOGAP00000002889; -.
DR Ensembl; ENSOGAT00000003236.2; ENSOGAP00000002889.2; ENSOGAG00000003235.2.
DR GeneID; 100943786; -.
DR KEGG; oga:100943786; -.
DR CTD; 163175; -.
DR eggNOG; ENOG502SHYJ; Eukaryota.
DR GeneTree; ENSGT00940000162018; -.
DR HOGENOM; CLU_036403_0_0_1; -.
DR InParanoid; H0WMD2; -.
DR OMA; WLLQWMA; -.
DR OrthoDB; 4083661at2759; -.
DR TreeFam; TF333155; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR GO; GO:0014009; P:glial cell proliferation; IEA:Ensembl.
DR GO; GO:0022011; P:myelination in peripheral nervous system; IEA:Ensembl.
DR GO; GO:0042551; P:neuron maturation; IEA:Ensembl.
DR GO; GO:0031641; P:regulation of myelination; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR009039; EAR.
DR InterPro; IPR005492; EPTP.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24367:SF268; LEUCINE-RICH REPEAT LGI FAMILY MEMBER 4; 1.
DR PANTHER; PTHR24367; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF03736; EPTP; 4.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01463; LRRCT; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50912; EAR; 6.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..537
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003543724"
FT DOMAIN 158..207
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REPEAT 210..252
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 256..298
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 351..394
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 396..439
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 441..483
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 487..532
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
SQ SEQUENCE 537 AA; 59305 MW; 5506C8034ACFBAC4 CRC64;
MGGPGILLLL LATVGMGVAW RPPKGKCPPP CSCSKDSALC EGSLDLPVNF SPTLLSLSLV
RTGVTQLKAG SFLRTPSLHL LLFTSNSFSV IEDDAFAGLS HLQYLFIEDN EIGSISKNAL
RGLRSLTHLS LANNHLEALP RFLFRGLETL THVDLRGNPF QCDCRILWLL QWMPTVNASV
GTGACAGPAA LAHMQLRHLD PKTFKCRGIE LSWFQTVGES ALGVEPFSYQ REPHIVLAQP
FAGRCLILSW DYSLQRFRPE EELSAPSVVS CKPLVLGPSL FVLAARLWGG SQLWARPSPG
LRLAPTQALA PRRLLRPNDA ELLWLDQQPC FVVADASKAG STTLLCRDGP GFYPRQSLHA
WHRDTDAEAL ELDGRPHLLL ASASQRPVLF HWSGGRFERR TDIPEAEDVY ATRHFQAGGD
VFLCLTRYIG DSMVMRWDGS MFRLLQQLPS RGAHVFQPLL IARDQLAILG SDFAFSQIFR
LEPDKGLLEP VQELGPPALV APRAFAHVTV DGRRFLFAAC FKGPTQIYQH HELDLSA
//
