ID H0WMJ2_OTOGA Unreviewed; 272 AA.
AC H0WMJ2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=DNA damage regulated autophagy modulator 1 {ECO:0000313|Ensembl:ENSOGAP00000002961.2};
GN Name=DRAM1 {ECO:0000313|Ensembl:ENSOGAP00000002961.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000002961.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000002961.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the DRAM/TMEM150 family.
CC {ECO:0000256|ARBA:ARBA00006565}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03016610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03016611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03016612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03016613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WMJ2; -.
DR STRING; 30611.ENSOGAP00000002961; -.
DR Ensembl; ENSOGAT00000003320.2; ENSOGAP00000002961.2; ENSOGAG00000003318.2.
DR eggNOG; KOG4320; Eukaryota.
DR GeneTree; ENSGT01030000234578; -.
DR HOGENOM; CLU_059992_2_2_1; -.
DR InParanoid; H0WMJ2; -.
DR OMA; WYFHVVS; -.
DR TreeFam; TF314508; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010506; P:regulation of autophagy; IEA:Ensembl.
DR InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR PANTHER; PTHR21324:SF11; DNA DAMAGE-REGULATED AUTOPHAGY MODULATOR PROTEIN 1; 1.
DR PANTHER; PTHR21324; FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED; 1.
DR Pfam; PF10277; Frag1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 272 AA; 30659 MW; D02371FA11396919 CRC64;
MLCFLRGMAF VPFLLVTWSS AAFIISYVVA VLSGHVNPFL PYISDTGTTP PESGIFGFMI
NFSAFLGAAT MYTRYKIVEK QNQTCYFSTP VFNLVSLVLG LVGCIGMGIV ANFQELAVPV
VHDGGALLAF VCGVLYTFLQ SIISYKSCPQ WNSLLTCHIR MTISAVSCAA VVPSILFYIC
HNEIHFVLYV SDVKTKLEWN PKEKDYIYHV VSAICEWTVA FGFIFYFLTF IHDFQKMSSF
DRGWVQTRHL RYMGLAPYPL GHRHHPLLTV SY
//
