ID H0WMS7_OTOGA Unreviewed; 1565 AA.
AC H0WMS7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=USP32 {ECO:0000313|Ensembl:ENSOGAP00000003069.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000003069.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000003069.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; AAQR03121827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03121828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03121829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03121830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03121831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03121832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03121833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03121834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03121835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000003069; -.
DR Ensembl; ENSOGAT00000003446.2; ENSOGAP00000003069.2; ENSOGAG00000003441.2.
DR eggNOG; KOG0044; Eukaryota.
DR eggNOG; KOG1870; Eukaryota.
DR GeneTree; ENSGT00940000155797; -.
DR HOGENOM; CLU_001060_10_1_1; -.
DR InParanoid; H0WMS7; -.
DR OMA; FKADNRR; -.
DR TreeFam; TF324190; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 3.
DR Gene3D; 3.30.2230.10; DUSP-like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR028135; Ub_USP-typ.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF76; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32; 1.
DR Pfam; PF06337; DUSP; 1.
DR Pfam; PF13202; EF-hand_5; 2.
DR Pfam; PF14836; Ubiquitin_3; 1.
DR Pfam; PF00443; UCH; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00695; DUSP; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF143791; DUSP-like; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS51283; DUSP; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 187..222
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 223..258
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 330..546
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT DOMAIN 695..1528
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1304..1393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1315..1364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1376..1391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1565 AA; 177321 MW; DF2C5456F480D416 CRC64;
ISEHSFMYFP SSQDVYKFKV EVIYCSFGGT SKGLHFNNLI VGLVLLTRGR DEEKAKYIFS
LFSSESGSYV VREEMERMLH VVDGKVPDTL RKCFSEGEKV NYEKFRNWLL LNKDAFTFSR
WLLSGGVYVT LTDDSDTPTF YQTLAGVTHL EESDIIDLEK RYWLLKAQSR TGRFDLETFG
PLVSPPIRPS LSEGLFNAFD ENRDNHIDFK EISCGLSACC RGPLAERQKF CFKVFDVDRD
GVLSRVELRD MVVALLEVWK DNRTDDIPEL HTDLSDIVEG ILNAHDTTKI GHLTLEDYQI
WSVKNVLANE FLNLLFQVCH IVLGLRPATP EEEGQIIRYR GWLERESRYG LQPGHNWFII
SMQWWQQWKE YVKYDANPVV IEPSSIMNGG KHPFGPPVHP MEQGEDRIGG SLSYVNNTEE
KFSDNISTAS EASETAGNSF LYSATPGADV CFARQHNTSD NNNQCLLGAN GNILLQLNPQ
KPGAIDNQPL VTQEPVKATS LTLEGGRLKR TPQLIHGRDY EMVPEPVWRA LYHWYGANLA
LPRPVIKNSK TDIPELELFP RYLLFLRQQP ASRTQQSNIW VNMGNVPSPN APLKRVLAYT
GCFSRMQTIK EIHEYLSQRL RIKEEDMRLW LYNSENYLTL LDDEDHRLEY LKIQDEQHLV
IEVRNKDMSW PEEMSFIANS SKIDRHKVPT EKGATGLSNL GNTCFMNSSI QCVSNTQPLT
QYFISGRHLY ELNRTNPIGM KGHMAKCYGD LVQELWSGTQ KNVAPLKLRW TIAKYAPRFN
GFQQQDSQEL LAFLLDGLHE DLNRVHEKPY VELKDSDGRP DWEVAAEAWD NHLRRNRSIV
VDLFHGQLRS QVKCKTCGHI SVRFDPFNFL SLPLPMDSYM HLEITVIKLD GTTPVRYGLR
LNMDEKYTGL KKQLSDLCGL NSEQILLAEV HGSNIKNFPQ DNQKVRLSVS GFLCAFEIPV
PASPVSSSSP TQTDFSSSPS TNGVFTLATN GDLPRPIFIP NGMPNTVVPC GTEKNFTNGL
VNGHMPSLPD NPFTGYIIAI HRKMMRTELY FLSSQKNRPS LFGMPLIVPC TVHTRKKDLY
DAVWIQVSRL ASPLPPQEAS NHAQDCDDSM GYQYPFTLRV VQKDGNSCAW CPWYRFCRGC
KIDCGEDKAF IGNAYIAVDW DPTALHLRYQ TSQERVVDEH ESVEQSRRAQ AEPINLDSCL
RAFTSEEELG ENEMYYCSKC KTHCLATKKL DLWRLPPILI IHLKRFQFVS GRWIKSQKIV
KFPRENFDPS AFLVPRDPAL CHRKPLTPQG DDLSEPRVLA GEVKKMDAQS SAGEEDVLLS
KSPSSLSANI ISSPKGSPSS SRKSGTSCPS SKNSSPNSSP RTLGRSKGRL RLPQIGSKNK
LSNSKENLDA SKENGAGQMC ELADALSRGH MLGGSQPELV TPQDHEVALA NGFLYEHEAC
GNGYSNGQLG NHSEEDSTDD QREDTRVKPI YNLYAISCHS GILGGGHYVT YAKNPNCKWY
CYNDSSCKEL HPDEIDTDSA YILFYEQQGI DYAQFLPKID GKKMADTSSM DEDFESDYKK
YCVLQ
//
