ID H0WN84_OTOGA Unreviewed; 281 AA.
AC H0WN84;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=RAB40C, member RAS oncogene family {ECO:0000313|Ensembl:ENSOGAP00000003266.2};
GN Name=RAB40C {ECO:0000313|Ensembl:ENSOGAP00000003266.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000003266.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000003266.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004423}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004423}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270}.
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DR EMBL; AAQR03077851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03077852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03077853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03077854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03077855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03077856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03077857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03077858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03077859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03077860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003790793.1; XM_003790745.2.
DR AlphaFoldDB; H0WN84; -.
DR STRING; 30611.ENSOGAP00000003266; -.
DR Ensembl; ENSOGAT00000003681.2; ENSOGAP00000003266.2; ENSOGAG00000003679.2.
DR GeneID; 100940822; -.
DR KEGG; oga:100940822; -.
DR CTD; 57799; -.
DR eggNOG; KOG0078; Eukaryota.
DR GeneTree; ENSGT00940000158979; -.
DR HOGENOM; CLU_041217_11_0_1; -.
DR InParanoid; H0WN84; -.
DR OMA; PMRGRMG; -.
DR OrthoDB; 5386089at2759; -.
DR TreeFam; TF323230; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd04121; Rab40; 1.
DR CDD; cd03742; SOCS_Rab40; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47980; LD44762P; 1.
DR PANTHER; PTHR47980:SF2; RAS-RELATED PROTEIN RAB-40C; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00176; RAN; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 175..228
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 245..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 281 AA; 31348 MW; 2A24946777BA85FC CRC64;
MGTQGSPVKS YDYLLKFLLV GDSDVGKGEI LESLQDGAAE SPYAYSNGID YKTTTILLDG
RRVKLELWDT SGQGRFCTIF RSYSRGAQGI LLVYDITNRW SFDGIDRWIK EIDEHAPGVP
RILVGNRLHL AFKRQVPTEQ ARAYAEKNCM TFFEVSPLCN FNVIESFTEL SRIVLMRHGM
EKIWRPNRVF SLQDLCCRAI VSCTPVHLID KLPLPVTIKS HLKSFSMANG MNAVMMHGRS
YSLASGAGGG SSKGNSLKRS KSIRPPQSPP QNCSRSNCKI S
//
