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Database: UniProt
Entry: H0WNE0_OTOGA
LinkDB: H0WNE0_OTOGA
Original site: H0WNE0_OTOGA 
ID   H0WNE0_OTOGA            Unreviewed;       795 AA.
AC   H0WNE0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   28-MAR-2018, entry version 39.
DE   RecName: Full=Delta-1-pyrroline-5-carboxylate synthase {ECO:0000256|PIRNR:PIRNR036429};
DE   Includes:
DE     RecName: Full=Glutamate 5-kinase {ECO:0000256|PIRNR:PIRNR036429};
DE              Short=GK {ECO:0000256|PIRNR:PIRNR036429};
DE              EC=2.7.2.11 {ECO:0000256|PIRNR:PIRNR036429};
DE     AltName: Full=Gamma-glutamyl kinase {ECO:0000256|PIRNR:PIRNR036429};
DE   Includes:
DE     RecName: Full=Gamma-glutamyl phosphate reductase {ECO:0000256|PIRNR:PIRNR036429};
DE              Short=GPR {ECO:0000256|PIRNR:PIRNR036429};
DE              EC=1.2.1.41 {ECO:0000256|PIRNR:PIRNR036429};
DE     AltName: Full=Glutamate-5-semialdehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036429};
DE     AltName: Full=Glutamyl-gamma-semialdehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036429};
GN   Name=ALDH18A1 {ECO:0000313|Ensembl:ENSOGAP00000003336};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000003336, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000003336}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000003336}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: ATP + L-glutamate = ADP + L-glutamate 5-
CC       phosphate. {ECO:0000256|PIRNR:PIRNR036429}.
CC   -!- CATALYTIC ACTIVITY: L-glutamate 5-semialdehyde + phosphate +
CC       NADP(+) = L-glutamyl 5-phosphate + NADPH.
CC       {ECO:0000256|PIRNR:PIRNR036429}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       glutamate 5-semialdehyde from L-glutamate: step 1/2.
CC       {ECO:0000256|PIRNR:PIRNR036429}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       glutamate 5-semialdehyde from L-glutamate: step 2/2.
CC       {ECO:0000256|PIRNR:PIRNR036429}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the gamma-
CC       glutamyl phosphate reductase family.
CC       {ECO:0000256|PIRNR:PIRNR036429}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the glutamate 5-
CC       kinase family. {ECO:0000256|PIRNR:PIRNR036429}.
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DR   EMBL; AAQR03047688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03047689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03047690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03047691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03047692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012659057.1; XM_012803603.1.
DR   STRING; 30611.ENSOGAP00000003336; -.
DR   Ensembl; ENSOGAT00000003756; ENSOGAP00000003336; ENSOGAG00000003752.
DR   GeneID; 100966445; -.
DR   CTD; 5832; -.
DR   eggNOG; KOG1154; Eukaryota.
DR   eggNOG; KOG4165; Eukaryota.
DR   eggNOG; COG0014; LUCA.
DR   eggNOG; COG0263; LUCA.
DR   GeneTree; ENSGT00500000044903; -.
DR   InParanoid; H0WNE0; -.
DR   OMA; MYVDSEA; -.
DR   OrthoDB; EOG091G02MP; -.
DR   TreeFam; TF314372; -.
DR   UniPathway; UPA00098; UER00359.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004349; F:glutamate 5-kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004350; F:glutamate-5-semialdehyde dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0019240; P:citrulline biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006536; P:glutamate metabolic process; IEA:Ensembl.
DR   GO; GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006592; P:ornithine biosynthetic process; IEA:Ensembl.
DR   CDD; cd07079; ALDH_F18-19_ProA-GPR; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 2.
DR   HAMAP; MF_00412; ProA; 1.
DR   HAMAP; MF_00456; ProB; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR020593; G-glutamylP_reductase_CS.
DR   InterPro; IPR001057; Glu/AcGlu_kinase.
DR   InterPro; IPR005715; Glu_5kinase/COase_Synthase.
DR   InterPro; IPR019797; Glutamate_5-kinase_CS.
DR   InterPro; IPR000965; GPR_dom.
DR   InterPro; IPR005766; P5_carboxy_syn.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036429; P5C_syn; 1.
DR   PRINTS; PR00474; GLU5KINASE.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   TIGRFAMs; TIGR01092; P5CS; 1.
DR   TIGRFAMs; TIGR00407; proA; 1.
DR   TIGRFAMs; TIGR01027; proB; 1.
DR   PROSITE; PS00902; GLUTAMATE_5_KINASE; 1.
DR   PROSITE; PS01223; PROA; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR036429};
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR036429};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Kinase {ECO:0000256|PIRNR:PIRNR036429};
KW   NADP {ECO:0000256|PIRNR:PIRNR036429};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR036429};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR036429};
KW   Proline biosynthesis {ECO:0000256|PIRNR:PIRNR036429};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Transferase {ECO:0000256|PIRNR:PIRNR036429}.
FT   DOMAIN       71    329       AA_kinase. {ECO:0000259|Pfam:PF00696}.
FT   DOMAIN      363    627       Aldedh. {ECO:0000259|Pfam:PF00171}.
SQ   SEQUENCE   795 AA;  87309 MW;  F39BDBBF243988AF CRC64;
     MLNQVYRCGF QPFNQRLLPW VQCTAVSRSH RVQPSAIRHV RSWSNIPFIT VPLSRTHGKS
     FAHRSELKHA KRIVVKLGSA VVTRGDECGL ALGRLASIVE QVSVLQNQGR EMMLVTSGAV
     AFGKQRLRHE ILLSQSVRQA LHSGQNQLKE MAIPVLEARA CAAAGQSGLM ALYEAMFTQY
     SICAAQILVT NLDFHDEQKR RNLNGTLHEL LRMNIVPIIN TNDAVVPPAE PNSDLQGVNV
     ISVKDNDSLA ARLAVEMKTD LLIVLSDVEG LFDSPPGSDD AKLIDIFYPG DQQSVTFGTK
     SRVGMGGMEA KVKAALWALQ GGTSVVIANG THPKVSGHVI TDIVEGKKVG TFFSEVKPAG
     PTVEQQGEMA RSGGRTLATL EPEQRAEIIH HLADLLTDQR DEILLANKKD MEEAEGRLAA
     PLLKRLSLST SKLNSLAIGL RQIASSSQDS VGRVLRRTRI AKNLELEQVT VPIGVLLVIF
     ESRPDCLPQV AALAIASGNG LLLKGGKEAA HSNRILHLLT QEALSIHGVK EAVQLVNTRE
     EVEDLCRLDK MIDLIIPRGS SQLVRDIQKA AKGIPVMGHS EGICHMYVDS EASVDKATRL
     VRDSKCEYPA ACNALETLLI HRDLLRTPLF DQIIDMLRVE QVKIHAGPKF ASYLTFSPSE
     VKSLRTEYGD LELCIEVVDN VQEAIDHIHK YGSSHTDVII TENEKTAEFF LHHVDSACVF
     WNASTRFSDG YRFGLGAEVG ISTSRIHARG PVGLEGLLTT KWLLRGQDHV VSDFSEHGSL
     KYLHENLPIP QRNTN
//
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