ID H0WNP0_OTOGA Unreviewed; 532 AA.
AC H0WNP0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Adhesion G protein-coupled receptor G5 {ECO:0000313|Ensembl:ENSOGAP00000003454.2};
GN Name=ADGRG5 {ECO:0000313|Ensembl:ENSOGAP00000003454.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000003454.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000003454.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAQR03092920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03092921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WNP0; -.
DR STRING; 30611.ENSOGAP00000003454; -.
DR Ensembl; ENSOGAT00000003887.2; ENSOGAP00000003454.2; ENSOGAG00000003884.2.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000161359; -.
DR HOGENOM; CLU_002753_3_9_1; -.
DR InParanoid; H0WNP0; -.
DR OMA; RIHVNLH; -.
DR TreeFam; TF321769; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR003910; GPR1/GPR3/GPR5.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF326; ADHESION G-PROTEIN COUPLED RECEPTOR G5; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01422; GPR56ORPHANR.
DR SMART; SM00303; GPS; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..532
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003544458"
FT TRANSMEM 248..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 489..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 252..511
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 532 AA; 59560 MW; 3670FCAD8810EFD4 CRC64;
MGCRGALFLC LCLLTFQTLM ADASEKLLHW MEKMERQRGR RMPSPDQQVH TLEQMLLNVS
FPGYNLTLQT STIQSLAFKL GCDFAGLALS SDTLKPVPQA QPVGGPRQAR DQHAMQFPAE
LTQDACRAQP GNLRLICIYF FTASFFKDDN NSSLLNNYIL GAQLSHGHVN NLRDPVNISF
WHNQSLDGYT LTCVFWKEGA SKHHWGAWSP EGCHTEQPSP SQVLCRCNHL TYFAVLMQLS
PAPVPAELLV PLTYISLVGC SISIVASLLT VLLHFHARKQ NDSITRIHMN LHASVLLLNV
AFLLSPMLAV PHVPRSACMV LAATLHYTLL SCLTWMAIEG FNLYLLLGRV YNIYIHRYVL
KLCALGWGLP ALLVLFLLAV KSSVYGLYTI PFSTSQENVT AFQNMSMCWV RNPVVHSILV
MGYGGLTSLF NLVVLAWALR ALRRLRARVE GQGARACRDT VTVLGLTMLL GTTWALAFFS
FGVFRLPQLF LFTIFNSLYG FFLFLWFCCQ RCHSEAEAQA EMEAFSSSQT VP
//
