ID H0WP42_OTOGA Unreviewed; 1504 AA.
AC H0WP42;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Nischarin {ECO:0000313|Ensembl:ENSOGAP00000003632.2};
GN Name=NISCH {ECO:0000313|Ensembl:ENSOGAP00000003632.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000003632.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000003632.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03061735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03061736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03061737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03061738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000003632; -.
DR Ensembl; ENSOGAT00000004079.2; ENSOGAP00000003632.2; ENSOGAG00000004076.2.
DR eggNOG; KOG1259; Eukaryota.
DR GeneTree; ENSGT00940000156494; -.
DR HOGENOM; CLU_252294_0_0_1; -.
DR InParanoid; H0WP42; -.
DR OMA; WSKNDLC; -.
DR TreeFam; TF320547; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR CDD; cd06875; PX_IRAS; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR037904; Nischarin_PX.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR PANTHER; PTHR15454:SF35; NISCHARIN; 1.
DR PANTHER; PTHR15454; NISCHARIN RELATED; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50195; PX; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 12..127
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 465..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1020..1106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..685
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1504 AA; 166587 MW; 1BB0BA0BD5A63BFF CRC64;
MAATARSFGP EREAEPAKEA RVVGSELVDT YTVYIIQVTD GSHEWTVKHR YSDFHELHEK
LVAEKKIDKN LLPPKKIIGK NSRSLVEKRE KDLEVYLQTL LAAFPGVAPR VLAHFLHFHF
YEINGITAAL AEELFEKGEQ LLGAGEVFAI GPLQLYAVTE QLQQGKPTCT SGDAKTDLGH
ILDFACRLKY LKVSGTEGPF GTSNIQEQLL PFDLSIFKAL HQVEISHCDA KHIRGLVASK
PTLATMSVRF SATSMKEVLV PEALEFDEWE PEGTALEGPV TAVIPTWQAL TTLDLSHNSI
SEIDESVKLI PKIEFLDLSH NGLLIVDNLQ HLYNLVHLDL SYNKLSSLEG VHTKLGNIKT
LNLAGNLLES LSGLHKLYSL VSLDLSSNRI EQMEEVRSIG SLPCLENVAL LNNPLSIIPD
YRTKVLAQFG ERASEVCLDD TVTTEKELDT VEVLKAIQKA KEVKSKLSNP EKKVGEDSRL
SASPGVRPSS SPPTVAPTSA SLPQPILSNQ GIMFVQEEAL ASSLSSTDSL TPEDRPIARG
CSDSLESIPA GQPTSDELRD VPGAVGGASP EHAEPEVQVV PGSGQIIFLP FTCIGYTATN
QDFIQRLSTL IRQAIERQLP AWIEAANQRE EGQARQREDD DEDEEEDVAE NRYFEMGPPD
TEEEEEGGRG EEEEEEEDEE AEEERLALEW ALGADEDFLL EHIRILKVLW CFLIHVQGSI
RQFAACLVLT DFGIAVFEIP HQESRGSSQH ILSSLRFVFC FPHGDLTEFG FLMPELCLVL
KVRHSENTLF IISDAANLHG FHVDLRSCFA PQHMAMLCSP ILYGSHTSLQ EFLRQLLTFY
KVAGGCQERS QGCFPVYLVY SDKRMVQTAA GDYSGNIEWA SCTLCSAVRR SCCAPSEAVK
SAAIPYWLLL TPQHLNVIKA DFNPMPNRGT HNCRNRNSFK LSRVPLSTVL LDPTRSCTQP
RGAFADGHVL ELLVGYRFVT AIFVLPHEKF HFLRIYNQLR ASLQDLKTVV IAKTPATGAI
PQRPLVDGQP AEGRASNDQH SQEAPAEAPA PAPAPAEVPA PAETPASTDA SAPAPAEASA
PSLVPEEAPV ETSAPAPAEA QAQAEYPSKH LIQSTSEENQ IPSHLPACPS LRHIASLPGS
AIIELFHSSI AEVENEELRH LMWSSVVFYQ TPGLEVTACV LLSTKAVYFV LHDGLRRYFS
EPLQDFWHQK NTDYNNSPFH ISQCFVLKLS DLQSVNVGLF DQYFRLTGSS PAQVVTCLTR
DSYLTHCFLQ HLMVVLSSLE RTPSPEPVDK DFYSEFGNKT TGKMENYELI HSSRVKFTYP
SEEEIGDLTF IVAQKMADPE KAPALSILLY VQAFQVSTPP PGRCRGPLRP KTLLLTSAEI
FLLDEDYIHY PLPEFAKEPP QRDRYRLDDG RRVRDLDRVL MGYQTYPQAL TLVFDDVQGH
DLMGNVTLDH FGEVPGGPAG AGQGREVQWQ IFVPSAESRE KLISLLARQW EALCGRELPV
ELTG
//
