ID H0WP46_OTOGA Unreviewed; 176 AA.
AC H0WP46;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Interleukin family protein {ECO:0000256|RuleBase:RU368043};
GN Name=IL20 {ECO:0000313|Ensembl:ENSOGAP00000003636.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000003636.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000003636.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Immune regulatory cytokine. {ECO:0000256|RuleBase:RU368043}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU368043}.
CC -!- SIMILARITY: Belongs to the IL-10 family.
CC {ECO:0000256|ARBA:ARBA00008813, ECO:0000256|RuleBase:RU368043}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03088768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003792255.1; XM_003792207.1.
DR AlphaFoldDB; H0WP46; -.
DR STRING; 30611.ENSOGAP00000003636; -.
DR Ensembl; ENSOGAT00000004083.2; ENSOGAP00000003636.2; ENSOGAG00000004081.2.
DR GeneID; 100965833; -.
DR KEGG; oga:100965833; -.
DR CTD; 50604; -.
DR eggNOG; ENOG502S5RZ; Eukaryota.
DR GeneTree; ENSGT00950000183124; -.
DR HOGENOM; CLU_098690_0_0_1; -.
DR InParanoid; H0WP46; -.
DR OMA; LQATESC; -.
DR OrthoDB; 5347451at2759; -.
DR TreeFam; TF333253; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045517; F:interleukin-20 receptor binding; IEA:Ensembl.
DR GO; GO:0045518; F:interleukin-22 receptor binding; IEA:Ensembl.
DR GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR InterPro; IPR020423; IL-10_CS.
DR InterPro; IPR020442; IL-20.
DR PANTHER; PTHR48394; INTERLEUKIN-19-RELATED; 1.
DR PANTHER; PTHR48394:SF4; INTERLEUKIN-20; 1.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01935; INTRLEUKIN20.
DR SMART; SM00188; IL10; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU368043};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR620443-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU368043};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU368043}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU368043"
FT CHAIN 25..176
FT /note="Interleukin family protein"
FT /evidence="ECO:0000256|RuleBase:RU368043"
FT /id="PRO_5031603423"
FT DISULFID 33..126
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-50"
FT DISULFID 80..132
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-50"
FT DISULFID 81..134
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-51"
SQ SEQUENCE 176 AA; 20047 MW; 40CF78AFBFAC5FD2 CRC64;
MKSSGLAFSL LSAVFYLLWT PSTGLKTLHL GSCVITTNLQ EIRNGFSEIR DSVQAKDGNM
DMRILRRTGS LQDTKPAGRC CLLRHLLRLY LDRVFKNYQT PDHHTLRKIS GLANSFLTIK
MDLRLCHAHM TCHCGEDAMK KYSHILSHFE ELEPQAAAVK ALGELDILLR WMEETE
//
