ID H0WP93_OTOGA Unreviewed; 1238 AA.
AC H0WP93;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Astrotactin 2 {ECO:0000313|Ensembl:ENSOGAP00000003690.2};
GN Name=ASTN2 {ECO:0000313|Ensembl:ENSOGAP00000003690.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000003690.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000003690.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03034806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03034807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03034808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03034809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03034810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03034811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03034812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03034813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03034814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03034815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000003690; -.
DR Ensembl; ENSOGAT00000004137.2; ENSOGAP00000003690.2; ENSOGAG00000004132.2.
DR eggNOG; ENOG502R4QT; Eukaryota.
DR GeneTree; ENSGT00390000003140; -.
DR HOGENOM; CLU_006316_1_0_1; -.
DR InParanoid; H0WP93; -.
DR TreeFam; TF332034; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0060187; C:cell pole; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0043533; F:inositol 1,3,4,5 tetrakisphosphate binding; IEA:Ensembl.
DR GO; GO:0048105; P:establishment of body hair planar orientation; IEA:Ensembl.
DR GO; GO:2000009; P:negative regulation of protein localization to cell surface; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:InterPro.
DR GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR040685; Annexin-like.
DR InterPro; IPR045574; ASTN1_2_Fn3.
DR InterPro; IPR045575; ASTN_1_2_N.
DR InterPro; IPR040510; ASTN_2_hairpin.
DR InterPro; IPR026995; Astrotactin.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR16592; -; 1.
DR PANTHER; PTHR16592:SF2; ASTROTACTIN-2; 1.
DR Pfam; PF18411; Annexin_2; 1.
DR Pfam; PF19743; ASTN1_2_fn3; 1.
DR Pfam; PF19441; ASTN_1_2_N; 1.
DR Pfam; PF18577; ASTN_2_hairpin; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 92..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 739..923
FT /note="MACPF"
FT /evidence="ECO:0000259|SMART:SM00457"
FT REGION 178..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1238 AA; 138762 MW; 0A40C1E118CC15F0 CRC64;
XAAESRLLLF VRNELPGRIA VQDDLDNTEL PFFTLEMSGT AADISLVHWR QQWLENGTLY
FHVSMSSSGQ LARATAPTLQ EPSEIVEEQM HILHISVMGG LIALLLLLLV FTVALYAQRR
WQKRHRIPQK SASTEATHEI HYIPSVLLGP QARESFRSSR LQAHNSVIGV PIRETPILDD
YDCEEDEEPP RRPNHVSRED EFSSQVTHSL DSLGRPGEEK VNFEKKAAAE ATQETVESLM
QKFKESFRAN TPIEIGHLQP APRSASAGKR KRRNKSRGGI SFGRAKGTSG SEADDETQLT
FYTEQYRSRR RSKGLLKSPM NKTALTLIAV NSCILAMVCG SQMSCPLTVK VTLHVPEHFI
ADGSSFVVSE GSYLDISDWL NPAKLSLYYQ INATSPWVRD LCGQRTTDAC EQLCDPETGE
CSCHEGYAPD PVHKHLCVRS DWGQSEGPWP YTTLERGYDL VTGEQAPEKI LRSTFSLGQG
LWLPVSKSFV VPPVELSINP LASCKTDVLV TEDPADVREE AMLSTYFETI NDLLSSFGPV
RDCSRNNGGC TRNFKCVSDR QVDSSGCVCP EELKPMKDGS GCYDHSKGID CSDGFNGGCE
QLCLQQTXXX XXXXXXXXFI LSCSCVEEYK LAPDGKSCLM LSDVCEGPKC LKPDSKFNDT
LFGEMLHGYN NRTQHVNQGE VFQMTFRENN FIKDFPQLAD GLLVIPLPVE EQCRGVLSEP
LPDLQLLTGD IRYDEAMGYP MVQQWRVRSN LYRVKLSSIT LSAGFTNVLK ILTKESSREE
LLSFIQHYGS HYIAEALYGS ELTCIIHFPS KKVQQQLWLQ YQKETTELGS KKELKSMPFI
TYLSGLLTAQ MLSDDQLISG VEIRCEEKGR CPSTCHLCRR PGKEQLSPTP VLLEINRVVP
LYTLIQDNGT KEAFKSALMS SYWCSGKGDV IDDWCRCDLS AFDASGLPSC SPLPQPVLRL
SPTVEPSSTV VSLEWVDVQP AIGTKVSDYI LQHKKVDEYT DTDLYTGEFL SFADDLLSGL
GTSCVAAGRS HGEVPEVSIY SVIFKCLEPD GLYKFTLYAV DTRGRHSELS TVTLRTACPL
VDDNKAEEIA DKIYNLYNGY TSGKEQQTAY NTLMEVSASM LFRVQHHYNS HYEKFGDFVW
RSEDELGPRK AHLILRRLER VSSHCSSLLR SAYIQSRVDT VPYLFCRSEE VRPAGMVWYS
ILKDTKITCE EKMVSMARNT YGESKGRYYL SLSKVSPF
//
