GenomeNet

Database: UniProt
Entry: H0WPC9_OTOGA
LinkDB: H0WPC9_OTOGA
Original site: H0WPC9_OTOGA 
ID   H0WPC9_OTOGA            Unreviewed;      1336 AA.
AC   H0WPC9;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   SubName: Full=Rho GTPase activating protein 33 {ECO:0000313|Ensembl:ENSOGAP00000003730.2};
GN   Name=ARHGAP33 {ECO:0000313|Ensembl:ENSOGAP00000003730.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000003730.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000003730.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PX domain-containing GAP family.
CC       {ECO:0000256|ARBA:ARBA00008795}.
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DR   EMBL; AAQR03125255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03125256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000003730; -.
DR   Ensembl; ENSOGAT00000004182.2; ENSOGAP00000003730.2; ENSOGAG00000004179.2.
DR   eggNOG; KOG1449; Eukaryota.
DR   GeneTree; ENSGT00940000155110; -.
DR   HOGENOM; CLU_009183_0_0_1; -.
DR   InParanoid; H0WPC9; -.
DR   OMA; SYGIREQ; -.
DR   TreeFam; TF351451; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04384; RhoGAP_CdGAP; 1.
DR   CDD; cd11835; SH3_ARHGAP32_33; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR15729:SF11; RHO GTPASE-ACTIVATING PROTEIN 33; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          231..293
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          360..555
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          28..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          597..841
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          911..1055
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1065..1084
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1139..1158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1164..1183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1195..1336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        617..631
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        662..693
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        719..758
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        795..830
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        921..946
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1017..1031
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1225..1242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1243..1258
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1336 AA;  143477 MW;  C676EA9AFF5B0C25 CRC64;
     GAISRPRAAL ALPFVSPRRR RRRWRRLALG IQDPPERNQA QSHLCSARST DSLDGPGEGS
     VQPLPPTGGP NVKGKPGKRL SAPRGPFPRL ADCAHFHYEN VDFGHIQQLL LSPDREGPSF
     SGENELVFGV QVTCQGRSWP VLRSYDDFRS LDAHLHRCIF DRRFSCLPEL PPPPEGARAA
     QMLVPLLLQY LETLSGLVDS NLNCGPVLTW MELDNHGRRL LLSEEASLNI PAVAAAHVVK
     RYTAQAPDEL SFEVGDIVSV IDMPPTEDRS WWRGKRGFQV GFFPSECVEL FTERPGPGLK
     ADSDGPSCGI PAPQGISSLT SAVPRPRGKL AGLLRTFMRS RPSRQRLRQR GILRQRVFGC
     DLGEHLSNSG QDVPQVLRCC SEFIEAHGVV DGIYRLSGVS SNIQRLRHEF DSERIPELSG
     PAFLQDIHSV SSLCKLYFRE LPNPLLTYQL YGKFSEAMSV PGEEERLVRV HDVIQQLPPP
     HYRTLEYLLR HLARMARHSA NTSMHARNLA IVWAPNLLRS MELESVGLGG AAAFREVRVQ
     SVVVEFLLTH VDVLFSDTFT SAGLDPAGRC LLPRPKSLAG SSPSTRLLTL EEAQARTQGR
     LGTPTEPTTP KAPASPVQRR KGERGEKQRK PGGSSWRTFF ALGRGPSVPR KKPLPWLGST
     RAPPQPSGNR SDTVTLRSAK SEESLSSQAS GAGLQRLHRL RRPHSSSDAF PVGPAPAGSC
     ESLSSSSSSS SSSSTSSSSS ESSAAGLGAL SGSPSHRTSA WLDDGDELDF SPPRCLEGLR
     GLDFDPLTFR CSSPTPGDPA PPASPAPPAP ASAFPPRATP QAPSPREPTS PASPTALDIS
     EPLSVSVPPA VLELLGAGGA PASVSPTPAV SPGPGLRPHL IPLLLHGAEA QLSDHCQQEI
     CSKLALPAPR GAQSQYGPGM DSPLLPPPLT LLRPGGAPPP PPKNPARLMA LALAERAQQV
     AERQSQQEHG GTPPAPHSPF HRSLSLEVGE EPLGTSGSGP PPHSVAQQDA WAPGLQSYLP
     RQQSDGSLVR GQRPIGTSRR GLRGPTPVST QLRAGGVYRD VPETAAQSPC SVPSQVPTPG
     FFSPAPRERL PPFLGVPKPG LYPVSPMSFQ SSSLAPVWRS SLGPPTPLDR GENLYYEIGA
     SEGSPYSGHT RSWSPFRSMP PDRLNASYGM VGQSPPLHRS PNFLLSYPTP PSCFPPDHLG
     YSAPQHPARR PTQPEPLYVN LSLGPRGSSP ASSCSSSPPA HPRSRSDPGP PAPRLPQKQR
     APWGPFTPHG VPGPWGPPES LQVYRAAPPA YGRGGELHRG SLYRNGGQRG EGAGPPPPYP
     TPSWSLHSEG QTRSYC
//
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