ID H0WPC9_OTOGA Unreviewed; 1336 AA.
AC H0WPC9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=Rho GTPase activating protein 33 {ECO:0000313|Ensembl:ENSOGAP00000003730.2};
GN Name=ARHGAP33 {ECO:0000313|Ensembl:ENSOGAP00000003730.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000003730.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000003730.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PX domain-containing GAP family.
CC {ECO:0000256|ARBA:ARBA00008795}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03125255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03125256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000003730; -.
DR Ensembl; ENSOGAT00000004182.2; ENSOGAP00000003730.2; ENSOGAG00000004179.2.
DR eggNOG; KOG1449; Eukaryota.
DR GeneTree; ENSGT00940000155110; -.
DR HOGENOM; CLU_009183_0_0_1; -.
DR InParanoid; H0WPC9; -.
DR OMA; SYGIREQ; -.
DR TreeFam; TF351451; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR CDD; cd11835; SH3_ARHGAP32_33; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF11; RHO GTPASE-ACTIVATING PROTEIN 33; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 231..293
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 360..555
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 28..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1164..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..830
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..946
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1225..1242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1243..1258
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1336 AA; 143477 MW; C676EA9AFF5B0C25 CRC64;
GAISRPRAAL ALPFVSPRRR RRRWRRLALG IQDPPERNQA QSHLCSARST DSLDGPGEGS
VQPLPPTGGP NVKGKPGKRL SAPRGPFPRL ADCAHFHYEN VDFGHIQQLL LSPDREGPSF
SGENELVFGV QVTCQGRSWP VLRSYDDFRS LDAHLHRCIF DRRFSCLPEL PPPPEGARAA
QMLVPLLLQY LETLSGLVDS NLNCGPVLTW MELDNHGRRL LLSEEASLNI PAVAAAHVVK
RYTAQAPDEL SFEVGDIVSV IDMPPTEDRS WWRGKRGFQV GFFPSECVEL FTERPGPGLK
ADSDGPSCGI PAPQGISSLT SAVPRPRGKL AGLLRTFMRS RPSRQRLRQR GILRQRVFGC
DLGEHLSNSG QDVPQVLRCC SEFIEAHGVV DGIYRLSGVS SNIQRLRHEF DSERIPELSG
PAFLQDIHSV SSLCKLYFRE LPNPLLTYQL YGKFSEAMSV PGEEERLVRV HDVIQQLPPP
HYRTLEYLLR HLARMARHSA NTSMHARNLA IVWAPNLLRS MELESVGLGG AAAFREVRVQ
SVVVEFLLTH VDVLFSDTFT SAGLDPAGRC LLPRPKSLAG SSPSTRLLTL EEAQARTQGR
LGTPTEPTTP KAPASPVQRR KGERGEKQRK PGGSSWRTFF ALGRGPSVPR KKPLPWLGST
RAPPQPSGNR SDTVTLRSAK SEESLSSQAS GAGLQRLHRL RRPHSSSDAF PVGPAPAGSC
ESLSSSSSSS SSSSTSSSSS ESSAAGLGAL SGSPSHRTSA WLDDGDELDF SPPRCLEGLR
GLDFDPLTFR CSSPTPGDPA PPASPAPPAP ASAFPPRATP QAPSPREPTS PASPTALDIS
EPLSVSVPPA VLELLGAGGA PASVSPTPAV SPGPGLRPHL IPLLLHGAEA QLSDHCQQEI
CSKLALPAPR GAQSQYGPGM DSPLLPPPLT LLRPGGAPPP PPKNPARLMA LALAERAQQV
AERQSQQEHG GTPPAPHSPF HRSLSLEVGE EPLGTSGSGP PPHSVAQQDA WAPGLQSYLP
RQQSDGSLVR GQRPIGTSRR GLRGPTPVST QLRAGGVYRD VPETAAQSPC SVPSQVPTPG
FFSPAPRERL PPFLGVPKPG LYPVSPMSFQ SSSLAPVWRS SLGPPTPLDR GENLYYEIGA
SEGSPYSGHT RSWSPFRSMP PDRLNASYGM VGQSPPLHRS PNFLLSYPTP PSCFPPDHLG
YSAPQHPARR PTQPEPLYVN LSLGPRGSSP ASSCSSSPPA HPRSRSDPGP PAPRLPQKQR
APWGPFTPHG VPGPWGPPES LQVYRAAPPA YGRGGELHRG SLYRNGGQRG EGAGPPPPYP
TPSWSLHSEG QTRSYC
//