ID H0WPN5_OTOGA Unreviewed; 320 AA.
AC H0WPN5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Cathepsin O {ECO:0000313|Ensembl:ENSOGAP00000003865.2};
GN Name=CTSO {ECO:0000313|Ensembl:ENSOGAP00000003865.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000003865.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000003865.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; AAQR03182834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03182835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003803057.1; XM_003803009.2.
DR AlphaFoldDB; H0WPN5; -.
DR STRING; 30611.ENSOGAP00000003865; -.
DR MEROPS; C01.035; -.
DR Ensembl; ENSOGAT00000004331.2; ENSOGAP00000003865.2; ENSOGAG00000004328.2.
DR GeneID; 100951115; -.
DR KEGG; oga:100951115; -.
DR CTD; 1519; -.
DR eggNOG; KOG1542; Eukaryota.
DR GeneTree; ENSGT00940000159253; -.
DR HOGENOM; CLU_012184_1_3_1; -.
DR InParanoid; H0WPN5; -.
DR OMA; FPHENST; -.
DR OrthoDB; 5472948at2759; -.
DR TreeFam; TF331594; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR PANTHER; PTHR12411:SF947; CATHEPSIN O; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..320
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018612584"
FT DOMAIN 107..319
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 320 AA; 35514 MW; 52F71EA66A6DC419 CRC64;
MELRALRWLL GLLCCCGGGG RAGSGATLPP TWPRSREREA AAFRESLNRH RYLNSLFPSE
NSTAFYGINQ FSYLFPEEFK AIYLRSKPSK FPRYPAELQM PIPNVSLPLR FDWRDKHVVT
QVRNQQTCGG CWAFSVVGAV ESACAIKGEP LEDLSVQQVI DCSYNNYGCN GGSTVNALNW
LNKMQVKLVK DSEYPFKAQN GLCHYFSGSH SGISIKDYSE YDFNEQEDEM AKALLTFGPL
VVIVDAVSWQ DYLGGIIQHH CSSGEANHAV LITGFDKTGS TPYWIVRNSW GSSWGVDGYA
HVKMGSNICG IADSVSAVFV
//
