ID H0WQP3_OTOGA Unreviewed; 775 AA.
AC H0WQP3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=TLE family member 3, transcriptional corepressor {ECO:0000313|Ensembl:ENSOGAP00000004285.2};
GN Name=TLE3 {ECO:0000313|Ensembl:ENSOGAP00000004285.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004285.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000004285.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR EMBL; AAQR03026223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WQP3; -.
DR STRING; 30611.ENSOGAP00000004285; -.
DR Ensembl; ENSOGAT00000004794.2; ENSOGAP00000004285.2; ENSOGAG00000004789.2.
DR eggNOG; KOG0639; Eukaryota.
DR GeneTree; ENSGT01030000234519; -.
DR HOGENOM; CLU_007612_3_0_1; -.
DR InParanoid; H0WQP3; -.
DR OMA; LTPDANW; -.
DR TreeFam; TF314167; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:1990907; C:beta-catenin-TCF complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF24; TRANSDUCIN-LIKE ENHANCER PROTEIN 3; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 34..149
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 575..616
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 617..658
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 146..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 42..76
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 157..171
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 775 AA; 83771 MW; ADC2E3CFEA0BDB51 CRC64;
SESLPLPAMY PQGRHPVSNC NSVYAPHQPG QPGFKFTVAE SCDRIKDEFQ FLQAQYHSLK
VEYDKLANEK TEMQRHYVMY YEMSYGLNIE MHKQTEIAKR LNTILAQIMP FLSQEHQQQV
AQAVERAKQV TMTELNAIIG QQQLQAQHLS HATHGPPVQL PPHPSGLQPP GIPPVTGSSS
GLLALGALGS QAHLTVKDEK NHHELDHREN NSVSPSESLR ASEKHRGSAD YSMEAKKRKA
EEKDSLSRYD SDGDKSDDLV VDVSNEDPAT PRVSPAHSPP ENGLDKGRGL KKDAPTSPAS
VASSSSTPSS KTKDLGHNDK SSTPGLKSNT PTPRNDAPTP GTSTTPGLRS MPGKPPGMDP
IASALRTPIS ITSSYATPFA MMGHHEMNGS LTSPSAYAGL HNIPPQMSAA AAAAAAAYGR
SPMVGFDPHP PMRATGLPSS LASIPGGKPA YSFHVSADGQ MQPVPFPHDA LAGPGIPRHA
RQINTLSHGE VVCAVTISNP TRHVYTGGKG CVKIWDISQP GSKSPISQLD CLNRDNYIRS
CKLLPDGRTL IVGGEASTLT IWDLASPTPR IKAELTSSAP ACYALAISPD AKVCFSCCSD
GNIAVWDLHN QTLVRQFQGH TDGASCIDIS HDGTKLWTGG LDNTVRSWDL REGRQLQQHD
FTSQIFSLGY CPTGEWLAVG MESSNVEVLH HTKPDKYQLH LHESCVLSLK FAYCGKWFVS
TGKDNLLNAW RTPYGASIFQ SKESSSVLSC DISADDKYIV TGSGDKKATV YEVIY
//
