ID H0WQU2_OTOGA Unreviewed; 673 AA.
AC H0WQU2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Synaptotagmin like 4 {ECO:0000313|Ensembl:ENSOGAP00000004352.2};
GN Name=SYTL4 {ECO:0000313|Ensembl:ENSOGAP00000004352.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004352.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000004352.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03140100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03140101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03140102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WQU2; -.
DR Ensembl; ENSOGAT00000004875.2; ENSOGAP00000004352.2; ENSOGAG00000004872.2.
DR GeneTree; ENSGT00940000159060; -.
DR HOGENOM; CLU_002711_5_0_1; -.
DR OrthoDB; 590187at2759; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd04029; C2A_SLP-4_5; 1.
DR CDD; cd04020; C2B_SLP_1-2-3-4; 1.
DR CDD; cd15764; FYVE_Slp4; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR044134; FYVE_Slp4.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR037303; SLP-4/5_C2A.
DR InterPro; IPR043567; SYTL1-5_C2B.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45716; BITESIZE, ISOFORM I; 1.
DR PANTHER; PTHR45716:SF4; SYNAPTOTAGMIN-LIKE PROTEIN 4; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50916; RABBD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 4..122
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 358..480
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 509..635
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 176..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 22..49
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 209..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 76396 MW; 2D2209DDE9015A05 CRC64;
MSEILDLSFL SEVERDLILN VLQRDEELRK ADEKRIRRLK NELLEIKRKG AKRGSQRYSD
RTCARCQESL GRLTPKTNTC RGCNHLVCRD CRIQESNGTW RCKVCAKEIE LKKATGDWFY
DQKVNRFAYH TGSEIIRMSL RRKPAVNKRE TVGQSLLYQT QMGDIWPGRK IIQEQQKEPS
VPFEVPKLKS GKSTLEAESE SLDSFTADSD STSRRDSLDK SGLFPEWKKM SAPKSQVEKE
TQPGGQNVVS VDEGEMIFKK NTRKILRPSE YTKSVIDLRP EDMGHESGSL GDRSKSVPGL
SVDMEEEEEE EEEDIDHLVK LHRQRLARSS MQSGSSMSTI GSMMSIYSEA GDFGNIFVTG
KIAFSLKYEQ QTQTLVIHVK ECHQLAYADE AKKRSNPYVK IYLLPDKSRQ GKRKTSIKRD
TVNPLYDEML RYEIPESLLA QRTLQFSVWH HGRFGRNTFL GEAEVQMDSW KLDKKLDHCL
PLHGKISAES PTGLPSHKGE LVVSLKYIPA SKLPVGGDRK KSKGGEGGEL QVWIKEAKNL
MAAKSGGTSD SFVKGYLLPM RNKASKRKTP VMKKTLNPHY NHTFVYNGVR LEDLQHMCLE
LTVWDREPLA SNDFLGGVRL GVGTGISNGE VVDWMDSTGE EVSLWQKMRQ YPGSWAEGTL
QLRSSMAKQK LGL
//
