UniProt: H0WR27

Database: UniProt
Entry: H0WR27_OTOGA

LinkDB:  H0WR27_OTOGA 
Original site:  H0WR27_OTOGA

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Ontology (16)   
   GO (16)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (13)   
   InterPro (7)   
   Pfam (2)   
   PROSITE (2)   
   SMART (2)   
All databases (36)   

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ID   H0WR27_OTOGA            Unreviewed;       495 AA.
AC   H0WR27;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   SubName: Full=Interferon regulatory factor 7 {ECO:0000313|Ensembl:ENSOGAP00000004454.2};
GN   Name=IRF7 {ECO:0000313|Ensembl:ENSOGAP00000004454.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004454.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000004454.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AAQR03181120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003802849.1; XM_003802801.2.
DR   AlphaFoldDB; H0WR27; -.
DR   STRING; 30611.ENSOGAP00000004454; -.
DR   Ensembl; ENSOGAT00000004989.2; ENSOGAP00000004454.2; ENSOGAG00000004986.2.
DR   GeneID; 100950073; -.
DR   KEGG; oga:100950073; -.
DR   CTD; 3665; -.
DR   eggNOG; ENOG502R2I9; Eukaryota.
DR   GeneTree; ENSGT00940000160931; -.
DR   HOGENOM; CLU_031544_2_0_1; -.
DR   InParanoid; H0WR27; -.
DR   OMA; HEIAQME; -.
DR   OrthoDB; 3740806at2759; -.
DR   TreeFam; TF328512; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0002753; P:cytoplasmic pattern recognition receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   GO; GO:0016064; P:immunoglobulin mediated immune response; IEA:Ensembl.
DR   GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
DR   GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0002819; P:regulation of adaptive immune response; IEA:Ensembl.
DR   GO; GO:0034124; P:regulation of MyD88-dependent toll-like receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0034127; P:regulation of MyD88-independent toll-like receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; IEA:Ensembl.
DR   CDD; cd00103; IRF; 1.
DR   Gene3D; 2.60.200.10; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR019817; Interferon_reg_fac_CS.
DR   InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR   InterPro; IPR019471; Interferon_reg_factor-3.
DR   InterPro; IPR017855; SMAD-like_dom_sf.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR   PANTHER; PTHR11949:SF2; INTERFERON REGULATORY FACTOR 7; 1.
DR   Pfam; PF00605; IRF; 1.
DR   Pfam; PF10401; IRF-3; 1.
DR   PRINTS; PR00267; INTFRNREGFCT.
DR   SMART; SM00348; IRF; 1.
DR   SMART; SM01243; IRF-3; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00601; IRF_1; 1.
DR   PROSITE; PS51507; IRF_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN          10..123
FT                   /note="IRF tryptophan pentad repeat"
FT                   /evidence="ECO:0000259|PROSITE:PS51507"
FT   REGION          138..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          238..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   495 AA;  54147 MW;  D73706A486F4B452 CRC64;
     MALTPERGAR VLFGEWLLHE ISSGYYEGLR WLDEAHTRFR VPWKHFGRRD LSEADARIFK
     AWAVARGRWP PSSRGDQLPP EATQRAGWKT NFRCALHSTR RFKLLEDNSW DLHDPHKVYA
     LRSTLGWRES PAIHQSEEDA LQNASPTQGG PPGPLLPKGD SELQDPCPLT APAGDMGDLL
     LQAVQESCLG DHLKAVCGAD LVPPQAPGGA ALSRDCVGGP QLPAGESQAA WAVEAAPHLG
     PQPLAPGTGL GAAPEPPYQA EPHPAPGPSM CPVAGEPSTG VLEVTVMYKG RAVLQEVVVC
     PRFVLLYGAP GPAVQAAEPQ LVVFPSPAAL PDQKQLRYTE ELLRHVAPGL QLELRGLRLW
     ARRMGKCKVY WEVGSPLGSA SPSNPACLLP RNHDTPIFDF GTFFQELVEF QARRRRGSPH
     YTIYLGFGQD LSAGRPKEKS LVLVKLEPWL CRTYLEGVQR EGVSSLDSSL SLCLSSTSSL
     YDDIERFLME LEQPA
//

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