ID H0WR90_OTOGA Unreviewed; 1389 AA.
AC H0WR90;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Kinesin family member 15 {ECO:0000313|Ensembl:ENSOGAP00000004528.2};
GN Name=KIF15 {ECO:0000313|Ensembl:ENSOGAP00000004528.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004528.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000004528.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. KIN-12 subfamily.
CC {ECO:0000256|ARBA:ARBA00034488}.
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DR EMBL; AAQR03112284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03112285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03112286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03112287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03112288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03112289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03112290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03112291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03112292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03112293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000004528; -.
DR Ensembl; ENSOGAT00000005068.2; ENSOGAP00000004528.2; ENSOGAG00000005062.2.
DR eggNOG; KOG4280; Eukaryota.
DR GeneTree; ENSGT00940000156463; -.
DR HOGENOM; CLU_005295_0_0_1; -.
DR InParanoid; H0WR90; -.
DR OMA; SEYNFKM; -.
DR TreeFam; TF320478; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01373; KISc_KLP2_like; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR031794; HMMR_C.
DR InterPro; IPR044986; KIF15/KIN-12.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR37739; KINESIN-LIKE PROTEIN KIN-12D; 1.
DR PANTHER; PTHR37739:SF8; KINESIN-LIKE PROTEIN KIN-12D; 1.
DR Pfam; PF15908; HMMR_C; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 26..363
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 1229..1250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 370..397
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 607..644
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 713..800
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 826..977
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1006..1047
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1087..1132
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1299..1384
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 109..116
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1389 AA; 160975 MW; AF136C37E9B77758 CRC64;
MAPGCKTELR NVTNCQSNQP SNEGDAIKVF VRIRPLAEGS GSADGEQSLC LSVLSSVSLR
LHSNPEPKIF TFDHVANMDT TQESVFSTVA KSIVESCMSG YNGTIFAYGQ TGSGKTFTMM
GPSESDNFSH HLRGVIPRSF EYLFSLIDRE KEKAGAGKSF LCKCSFIEIY NEQIFDLLDS
ASAGLYLREH IKKGVFVVGA VEQVITSAAE AYQVLSGGWR NRRVASTSMN RESSRSHAVF
TIIIESMEKS NEIVNIRTSL LNLVDLAGSE RQKDTHAEGM RLKEAGNINR SLSCLGQVIT
ALVDVGNGKQ RHVCYRDSKL TFLLRDSLGG NAKTAIIANV HPGSRCFGET LSTLNFAQRA
KLIKNKAVVN EDTQGNVIQL QAEVKRLKEQ LAQLTSGRTP PESFLTRDKE KTDYMKYFQE
AMLFFKKSEQ EKKSLIEKIT QLEDLNLKKE KFIQSNKMIV KFREDQIIRL EKLHKESRGS
FLAEEQDRLL SELRDEIQTL REQIEHHPRV AKYAMENHSL REENRRLRLL DPVKIAQEMD
AQTIAKLEKA FTEVCDTEKN DKSKKWLIDR ARKYPHCLYF IDKKIYSVLT FNYYCYYYCD
KSYPEFKDIT KKRQLELESE LQSLQKANLN LENLLEATKA CKRQEVSQLN KIHAETLKII
TTPTKAYQLR SRLVPKLSPE SGIFGSIHTQ NSNLLDNDIL NEPVPPEMNE QAFEAISEEL
RTVQEQMSAL QVKLDEEEHK NLKLQQHVDK LEHHSTQMQE LFASERTDWT KHQQELLSQL
NVLEKQFRDT QTKNDFLKSE VHDLRVVLHS ADKELSSVKL EYSSFKENQE QELNNLSERH
MHVQLQLDNV RLENEKLLEN KACLQDSYDN LQEVMKFETD QLSKNLQNYK KENETLKSDL
KNLMELFEAE KERNNKLSLQ FEEDKENSSK EILKVLEAVR QEKQKEMAKC EQQMAKVQKL
EENLLATEKV ISSLEKSIDS DKEVVSDLMN QIQELRTSVC KKTEIIDTLE QELKDINCKY
NSALVDKEES KALIKRQEGD ILDLQETLRL RILSEDIERD MLCEDLAHAT EQLNMLTEAS
TKHLGLLQSA QEELTKKEAL IQELQHKLNQ KKEEVEQRKN EYNFKMKQLE HVMDSAAEVP
QSPKSPPPFP THLAKLLETQ EQEIEDGRAS KTSLERLVTM LNEDREVKNA EILRMKEQLC
EMENLRLESQ QLREKNWLLQ GQLDDLKRQK DNSHQNHPDN QQLKNEEEEI VNERHAKSKI
VEEMLKMKAD LEEVQSALHN REMDCLRVAE EVERTRTLES KAFQEKEELR SKLEEMYEER
ERAFQEMEML RKQVEYLAEE NGKLVGHQNL HQKIQYVVRL KKENVRLTEE TEKLRAENVF
LKEKKKNES
//
