ID H0WRA3_OTOGA Unreviewed; 658 AA.
AC H0WRA3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=DNA helicase MCM9 {ECO:0000256|ARBA:ARBA00041085};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 9 {ECO:0000256|ARBA:ARBA00042301};
GN Name=MCM9 {ECO:0000313|Ensembl:ENSOGAP00000004545.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004545.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000004545.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
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DR EMBL; AAQR03004307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03004308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WRA3; -.
DR STRING; 30611.ENSOGAP00000004545; -.
DR Ensembl; ENSOGAT00000005087.2; ENSOGAP00000004545.2; ENSOGAG00000005084.2.
DR eggNOG; KOG0477; Eukaryota.
DR GeneTree; ENSGT01090000260080; -.
DR HOGENOM; CLU_000995_7_2_1; -.
DR InParanoid; H0WRA3; -.
DR OMA; HYVKQHF; -.
DR TreeFam; TF329421; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0097362; C:MCM8-MCM9 complex; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0032406; F:MutLbeta complex binding; IEA:Ensembl.
DR GO; GO:0032407; F:MutSalpha complex binding; IEA:Ensembl.
DR GO; GO:0032408; F:MutSbeta complex binding; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0070716; P:mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication; IEA:Ensembl.
DR GO; GO:0071168; P:protein localization to chromatin; IEA:Ensembl.
DR GO; GO:0036298; P:recombinational interstrand cross-link repair; IEA:Ensembl.
DR CDD; cd17760; MCM9; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF48; DNA HELICASE MCM9; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 306..509
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 658 AA; 73968 MW; ED267F6E1E561043 CRC64;
PKFKMNSDQV ALVGQVFESY VSEYHKNDIL LILKERDEDA HYAVVVNAMT LFETNMEIGE
YFTVFPNEVL SVFDSALRRS ALTILQSLSQ PECVSMKQNL HARISGLPVC PELVREHIPK
TKDVGHFLSV TGTVIRTSLV KVLEFERDYM CNKCKHIFVV KADFEQYYTF CRPSSCPSLE
SCDSSKFTCL SSLSSSPTRC RDYQEIKIQE QVQRLSVGSI PRSMKVVLED DLVDSCKSGD
DLTIYGVVMQ RWKPFQQDVR CEVEIVLKAN YVQVNNEQSS GITMDEEVRK EFEDFWECYK
SDPFAGRNEI LASLCPQIFG MYLVKLAVAM VLAGGIQRTD ATGTRVRGES HLLLVGDPGT
GKSQFLKYAA KITPRSVLTT GIGSTSAGLT VTAVKDSGEW NLEAGALVLA DAGLCCIDEF
NSLKEHDRTS IHEAMEQQTI SVAKAGLVCK LNTRTTILAA TNPKGQYDPQ ESVSVNIALG
SPLLSRFDLI LVLLDTKNED WDRIISSFIL ENKGYPSKSE KLWSMEKMKT YFCLIRNLQP
SLSDVGNQVL LRYYQMQRQS DARNAARTTI RLLESLIRLA EAHARLMFRD TVTLEDAITV
VSVMESSMQG GALLGGVNAL HTSFPENPRE QYQRQCELIL EKLELQSLLS EELRRLER
//
