ID H0WRF3_OTOGA Unreviewed; 623 AA.
AC H0WRF3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Arginyl aminopeptidase like 1 {ECO:0000313|Ensembl:ENSOGAP00000004606.2};
GN Name=RNPEPL1 {ECO:0000313|Ensembl:ENSOGAP00000004606.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004606.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000004606.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR634015-3};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR634015-3};
CC -!- SIMILARITY: Belongs to the peptidase M1 family.
CC {ECO:0000256|ARBA:ARBA00010136}.
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DR EMBL; AAQR03144426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WRF3; -.
DR STRING; 30611.ENSOGAP00000004606; -.
DR Ensembl; ENSOGAT00000005150.2; ENSOGAP00000004606.2; ENSOGAG00000005146.2.
DR eggNOG; KOG1047; Eukaryota.
DR GeneTree; ENSGT00940000160400; -.
DR HOGENOM; CLU_014505_1_2_1; -.
DR InParanoid; H0WRF3; -.
DR OMA; GVYHFHM; -.
DR TreeFam; TF300758; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09599; M1_LTA4H; 1.
DR Gene3D; 3.30.2010.30; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 1.25.40.320; Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain; 1.
DR Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR InterPro; IPR045357; Aminopeptidase_N-like_N.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038502; M1_LTA-4_hydro/amino_C_sf.
DR InterPro; IPR034015; M1_LTA4H.
DR InterPro; IPR001930; Peptidase_M1.
DR InterPro; IPR015211; Peptidase_M1_C.
DR InterPro; IPR014782; Peptidase_M1_dom.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR45726:SF2; AMINOPEPTIDASE RNPEPL1; 1.
DR PANTHER; PTHR45726; LEUKOTRIENE A-4 HYDROLASE; 1.
DR Pfam; PF09127; Leuk-A4-hydro_C; 1.
DR Pfam; PF01433; Peptidase_M1; 1.
DR Pfam; PF17900; Peptidase_M1_N; 1.
DR PRINTS; PR00756; ALADIPTASE.
DR SMART; SM01263; Leuk-A4-hydro_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR634015-3};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR634015-3}.
FT DOMAIN 472..617
FT /note="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase
FT C-terminal"
FT /evidence="ECO:0000259|SMART:SM01263"
FT ACT_SITE 298
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR634015-1"
FT ACT_SITE 386
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR634015-1"
FT BINDING 297
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR634015-3"
FT BINDING 301
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR634015-3"
FT BINDING 320
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR634015-3"
SQ SEQUENCE 623 AA; 70048 MW; 7AA0FEA2A8541A50 CRC64;
DVASASSAQL FRLRHLQLGL ELRPEARELA GCLVLELCAL RPAPRALVLD AHPALRLHSA
AFRRAFPEAP GAEPACCPLA FRLDPFTDYG SSLTVTLPPE LQAHQPFQVI LRYTSTDAPA
IWWLEPELTY GCAKPFVFTQ GHSVCNRSFF PCFDTPAVKS TYSAVVKAPS GVQVLMSATQ
SAYVEEEGIF RFHMEHPVPA YLVALVAGDL KPADIGPRSR VWAEPCLLPT ATSKLSGVVE
QWLSAAERLY GPYMWGRYDI VFLPPSFPIV AMENPCLTFI ISSILESDEF LVIDVIHEVA
HSWFGNAVTN ATWEEMWLSE GLATYAQRRI TTETYGAAFT CLETAFRLDA LHRQMKLLGE
DSPVSKLQVK LEPGVNPSHL MNLFTYEKGY CFVYYLSQLC GDPQRFDDFL RAYVEKYKFS
SVVAQDLLDS FLSFFPELKE QSVDCRAGLE FERWLNATGP PLAEPDLSQG SSLTRPVEAL
FQMWTAEPLD QAAASASAID ISKWRTFQTA LFLDRLLDGS PLPQEVVTSL SKCYSSLLDS
MNAEIRIRWL QIVVRNDYYP DLHRVRRFLE SQMSRMYTIP LYEDLCTGAL KSFALEVFYQ
TQGRLHPNLR RTIQQILSQG LGP
//
