ID H0WS41_OTOGA Unreviewed; 667 AA.
AC H0WS41;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=RNA polymerase II-associated protein 3 {ECO:0000256|ARBA:ARBA00040133};
GN Name=RPAP3 {ECO:0000313|Ensembl:ENSOGAP00000004881.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004881.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000004881.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RPAP3 family.
CC {ECO:0000256|ARBA:ARBA00038275}.
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DR EMBL; AAQR03104192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03104193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03104194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03104195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03104196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03104197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03104198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03104199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03104200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WS41; -.
DR STRING; 30611.ENSOGAP00000004881; -.
DR Ensembl; ENSOGAT00000005458.2; ENSOGAP00000004881.2; ENSOGAG00000005454.2.
DR eggNOG; KOG4648; Eukaryota.
DR GeneTree; ENSGT00940000156749; -.
DR InParanoid; H0WS41; -.
DR OMA; NFTPDRP; -.
DR TreeFam; TF106243; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0097255; C:R2TP complex; IEA:Ensembl.
DR GO; GO:1990062; C:RPAP3/R2TP/prefoldin-like complex; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR025986; RPAP3-like_C.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46423; RNA POLYMERASE II-ASSOCIATED PROTEIN 3; 1.
DR PANTHER; PTHR46423:SF1; RNA POLYMERASE II-ASSOCIATED PROTEIN 3; 1.
DR Pfam; PF13877; RPAP3_C; 1.
DR Pfam; PF00515; TPR_1; 2.
DR Pfam; PF13432; TPR_16; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 133..166
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 201..234
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 282..315
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 350..383
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 545..635
FT /note="RNA-polymerase II-associated protein 3-like C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF13877"
FT REGION 37..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 75754 MW; B05B4A6BAFC1168C CRC64;
MTSTNKAIEL QLQVKQNAEE LQDFMRDLEN WEKDIKQKDM ELRRQNGVPE ENLPPIRNRN
FRKKKKGKAK EPSKKTKEEN TKNRIKSYDY EAWAKLDVDS ILDELDKEDS THDSLSQESE
SEEDGIRVDS QKALALKEKG NKYFKQGKYD EAIECYTKGM DADPYNPVLA TNRASAFFRL
KKFAVAESDC NLAIALNRSY TKAYARRGAA RFALQKLEDA KKDYEKVLEL EPNNFEATNE
LRKINQALTS KENSYPKEAD VMIKSPEGEK KHTEDQQNKQ QAVSEKDLGN AFFKEGKYER
AIECYTRGIA ADGANALLPA NRAMAYLKIQ KYEEAEKDCT HAILLDGSYS KAFARRGTAR
TFLGKLSEAK QDFETVLLLE PGNKQAVTEL SKIKKELIEK GHWDDVFLDS TQRQNLVKPM
DNPPHLGSAK LLKKVIIEET GNLIQTIDVP DSTTAAAPES NPINLANVIA TTGTASKNSS
QDDLLPTSDT PRAKVLKIEE ISATSALQPQ ASLKQDVCQS SSGKNSTEIE QTPAQFVSAV
LPAVPANSFQ LESDFRQLKS SPDMLYKYVK QIEPSLYPKL FQKNLDPDVF NQIIKILHDF
YIEKEKPSLI FEILQRLSEL KRFDMAVMFM SETEKKIAHV LFNHLEKSGL EDNSLEELKK
RYDTFFS
//
