ID H0WSL8_OTOGA Unreviewed; 417 AA.
AC H0WSL8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Sprouty-related, EVH1 domain-containing protein 2 {ECO:0000256|ARBA:ARBA00039299};
GN Name=SPRED2 {ECO:0000313|Ensembl:ENSOGAP00000005085.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000005085.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000005085.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasmic vesicle,
CC secretory vesicle membrane {ECO:0000256|ARBA:ARBA00004360}; Peripheral
CC membrane protein {ECO:0000256|ARBA:ARBA00004360}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004360}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; AAQR03102535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03102536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03102537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03102538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03102539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03102540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WSL8; -.
DR STRING; 30611.ENSOGAP00000005085; -.
DR Ensembl; ENSOGAT00000005693.2; ENSOGAP00000005085.2; ENSOGAG00000005690.2.
DR eggNOG; KOG4590; Eukaryota.
DR GeneTree; ENSGT00940000156841; -.
DR HOGENOM; CLU_038867_1_1_1; -.
DR InParanoid; H0WSL8; -.
DR OMA; CEYAPDT; -.
DR TreeFam; TF321411; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd10574; EVH1_SPRED-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR023337; KBD.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041937; SPRE_EVH1.
DR InterPro; IPR007875; Sprouty.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR11202:SF11; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF05210; Sprouty; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51488; KBD; 1.
DR PROSITE; PS51227; SPR; 1.
DR PROSITE; PS50229; WH1; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 5..122
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 202..257
FT /note="KBD"
FT /evidence="ECO:0000259|PROSITE:PS51488"
FT REGION 127..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 47542 MW; 2352159914432A83 CRC64;
TSSKTHNFSD SYIVRVKAVV MTRDDSSGGW FPQEGGGISR VGVCKVMHPE GNGRSGFLIH
GERQKDKLVV LECYVRKDLV YTKANPTFHH WKVDNRKFGL TFQSPADARA FDRGVRKAIE
DLIEGSTTSS STIHNEAELG DDDVFTTATD SSSNSSQKRE QPTRTISSPT SCEHRRIYTL
GHIHDPYPTD HYHLDQQPMP RPYRQVSFPD DDEEIVRINP REKIWMTGYE DYRHAPVRGK
YPDPSEDADY YVRFAKGEVP KHDYNYPYVD SSDFGLEDPK GRGGGVIKTQ PPRGKSRRRK
EDGERSRCVY CRDMFNHEEN RRGHCQDAPD SVRTCIRRVS CMWCADSMLY HCMSDPEGDY
TDPCSCDTSD EKFCLRWMAL IALSFLAPCM CCYLPLRACY HCGVMCRCCG GKHKAAA
//
