ID H0WT11_OTOGA Unreviewed; 1366 AA.
AC H0WT11;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000005256.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000005256.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03057974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03057975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000005256; -.
DR Ensembl; ENSOGAT00000005879.2; ENSOGAP00000005256.2; ENSOGAG00000005869.2.
DR eggNOG; KOG0192; Eukaryota.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000165193; -.
DR HOGENOM; CLU_001731_0_0_1; -.
DR InParanoid; H0WT11; -.
DR OMA; ARMEVSM; -.
DR TreeFam; TF313679; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0048583; P:regulation of response to stimulus; IEA:UniProt.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR032171; COR.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR020859; ROC_dom.
DR PANTHER; PTHR23257:SF979; LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 1; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF08477; Roc; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS51424; ROC; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 1..180
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
FT DOMAIN 596..879
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1201..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1366 AA; 153146 MW; E422E73F60E85E85 CRC64;
PRQGKSTLLE ILQTGRPPQV MHEEVTIRTT KWELQRPAGS RAKVDSVEFN VWDIGGPASM
ATVNQCFFTD KALYVVVWNL ALGEEAVASL QFWLLNIEAK APNAVVLVVG THLDLIEAKF
RVERIATLRA YVLALCRSPS GSRATGFPDI TFKHLHEISC KSLEGQEGLR QLIFHVTCNM
KDVGSTIGCQ RLAGRLIPRS YLSLQEAVLA EQQWRSQADD VQYLTDKQLE QLVEQTPDND
IKDYEDLQSA IGFLIETGTL LHFPDTSHGL RNLYFIDPIW LSECLQRIFT IKGSRSVAKN
GVIRAEDLRM LLVGTGFTQQ TEEQYFQFLA KFEIALPVAN DSYLLPHLLP SKPGLDTHGM
RHPAANTIQR VFKMSFVPVG FWQRFIARML ISLAEMDLQL FENKKNTKSR NRKVTIYSFT
GNQRNRCSTF RVKRNQTIYW QEGLLVTFDG GYLSVESSDV NWKKKKSGGI KIICQSEMRD
FSAMAFITDH INSLIDQWFP ALTATESDGT PLMEQYVPCP VCETSWAQHG DLGERSEDVQ
YFDMEDCVLT AIERDFISCP RHPDLPVPLQ ELVPELFMTD FPARLFLENS RLEHSEDEGS
ILGQGGSGTV IYHARYQGQP VAVKRFQIKK FKNFANAPAD TMLRHLRAMD AMKNFSEFRQ
EASMLHALQH PCIVSLIGIS IHPLCFALEL APLSSQFTIY FLSLQDSSFM PLGHMLTQKI
AYQIALGLAY LHKKNIIFCD LKSDNILVWS HDVKEPINIK LSDYGISRQS FHEGALGVEG
TPGYQAPEIR PRIVYDEKVD MFSYGMVLYE LLSGQRPALG HHQLQIAKKL SKGIRPVLGQ
LEEVQFYRLQ ALMMECWDTK PEKRPLALSV VSQMKDPTFA TFMYMLPCGK QLAFFSSQGQ
EYTVVFWDGK EESRNYTVVN TEKGLLEVQR MSCPGMKLSC QLKVQSSLWT ATEDQKIYIY
SLKGMCPLNM PQRALDTPAV VTCFLAVPVI KKNSYLVLAG LADGLVAVFP VARGSPTDSC
SYLCSHTANR SKFGISDEDV RQNPYPVKAM EVVNSGSEVW YSNGPGLLVI DCAALDITRR
LEPYSAPSVV VSVVCGSDGK GEEVVWCLDD KANSLVMYHS ATYQLCARYF CGDPSPLRDT
FPVGPLAMEA PSSHEACMKE GEPIMDVSIM FSGELGTQIL THQDSLTDYC SMSSYSSSPP
CRAARSPSSL PSSPASSSSV PFSTDCEDSD RLHEPSATSD RSEHDLSPID GETFSQHLQA
VKVLAVRDLI WVPRRGGDII VIGLEKDGGV QRGRVIAILK ARELTPHGVL VDAAVVAKDT
VVCGFENENT EWCLAVWRGW GAREFDIFYQ SYEELGRLEA CTRKRR
//
