ID H0WT19_OTOGA Unreviewed; 2426 AA.
AC H0WT19;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Mucin 6, oligomeric mucus/gel-forming {ECO:0000313|Ensembl:ENSOGAP00000005267.2};
GN Name=MUC6 {ECO:0000313|Ensembl:ENSOGAP00000005267.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000005267.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000005267.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR EMBL; AAQR03181074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03181075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03181076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000005267; -.
DR Ensembl; ENSOGAT00000005894.2; ENSOGAP00000005267.2; ENSOGAG00000005890.2.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000161708; -.
DR HOGENOM; CLU_000076_1_0_1; -.
DR InParanoid; H0WT19; -.
DR OMA; GSNIEGC; -.
DR TreeFam; TF300299; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR CDD; cd19941; TIL; 3.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF264; MUCIN-6; 1.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF01826; TIL; 2.
DR Pfam; PF00094; VWD; 3.
DR SMART; SM00832; C8; 3.
DR SMART; SM00041; CT; 1.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 3.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 3.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS51233; VWFD; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..2426
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003543933"
FT DOMAIN 43..214
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 395..579
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 866..1038
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2336..2425
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT REGION 1205..1747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1763..1867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1880..2145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2206..2303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1205..1219
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1220..1747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1880..1994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2002..2145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2426 AA; 257622 MW; 5180FBD499442EB4 CRC64;
LLRLLLLLSN GGALLSTGLD NTFFARPGLW KSEDSPQIDP DKGWCSTWGT GHFSTFDHHV
YDFLGTCNYV FTATCKDASP TFSVQLRRGL DGNISRIIME LGASVITVSK ATISVKDIGV
ISLPHTSNGL QITPFGQSVR LVAKQLELEL EVLWSPDAHL TVLVERKYMG RMCGLCGNFD
GKTANEFLSE EGKLLEPHKY AALQKLDDPN EICAYEAVPR PPVWQTKHAQ ICTQLLALVS
PECNVPKSPF VLSCQADMAT ATQPGQQDSK CATLSEYSRQ CSMAGQPVRS WRRPGLCAVG
PCPAGQVYQE CGSACVRTCS NPQHHCSSFC TFGCFCPEGT VLNDLSTNHT CVPVTQCPCV
LNGAIYAPGD ITTTACRTCQ CTSARWTCTE HPCPGHCSLE GGSFVTTFDA RPYRFHGSCT
YILLQSPQLP DEGTLMAVYD KSGYSHSETS LAAVIYLSKQ VKIVISQDGV ITNNEDPKWL
PYQIRNITVF RQTSTHLQMA TTFGLELVIQ LQPIFQVYVT VGSKFRGHTR GLCGNFNGDT
TDDFMTSVGI AEGTASLFVD SWRAGNCPAA LERETDPCSM SQLNKVCAET HCSVLLRKGT
VFERCHATVN PAPFYKRCVY EACNYEETFP HICATLGSYA HACSSQGILL WGWRSSVDNC
TIPCSGNRTF SYDSRACGRT CLSLSDRAVE CQPSAVPVDG CNCPEGTYLN HRGECVRRAQ
CPCVLEGGRL IPAGQSTVID SVACHCTGGR LSCPGRPQMF FASCSALKTF QSCSQSSENK
FGAACAPTCQ LLATGTPCVP TKCEPGCVCA EGLYENASGQ CVPPEECPCE FAGTSYPGGA
KLHTDCRTCT CSRGKWTCQQ SLHCPSTCAL YGEGHVVTFD GQRFVFDGNC EYILATDGCG
TNDSQPTFKI LTENVICGRS GVTCSRAIKI FSGGLSIVLA DSNYTVTGED PRVHLRVKPS
SLNLILDISI PGRYSLTLIW NKHMTIFIKI DRASQDPLCG LCGNYNGNMK DDFETRSKYV
AANELEFVNS WKESPLCGDV SFLAEPCSLN AFRRSWAERK CSIINSQTFA ACHSKVYHLP
YYEACVRDAC GCDTGGDCEC LCDTVAAYAK ACLDKGVCVD WRTPAFCPIY CDFYNTHTQV
GGSGELQHTQ EANCTWHYQP CLCPGQPESL LDTNIEGCYN CSQDEYFDHK RGSCVPCVPP
TTPWPPTTGH MPHPGSPPTE VQPTTVTHST IGHRSTPEPW PSPTQTPQLL TTRPSGLSTK
STVSSSSMEE SPRTTTVVTP RTTVPAPTAT RPTMTQANTQ PTASSLSPAT KLTAQSTVWT
TVPPETSAVS GTSPRIAEST NQASTGPTAN QTPDNTGPAT TSKTTRGITT HPGQTSPPET
WTQTSQTLTT STATTSPHPH TTHTPSTGSL PSTTHTRGPP TEMSFKTTSI TPSAPNHHTT
LPAHVPSSST SLVTQTAHQG STTTHSEIPT TSMPKSTPTR RPTTTVKETG STSPFTVTNQ
PMSPFTTAKT SSSQHSQTAS TSHHQPTASN ATTITPRLTT SDTGPTMVKS TTSANNRPHT
PLMTNSPSTG SLPHTPHTTR PPSGTSFKTS STAPTPTRPH TILSTYIPSS STSLVTQTAH
QGSTPTHSEI PTSNSTLTST STRLPITTLK ATGSTSPFTT TSLSSSPFST AKTSSQHSQT
ASTSHHQPTT STATTITPNF TTSATGPATG STSPFTGTSQ PQSPFTTAKT SSSQHSQTAS
TSHHQSTATY ATTITAELTT ITPKLTTSDN GPTMLQSTTP TNSLPHTPHT THSPSTGSLP
SIPHTTGPPF GTSFKTTSST VLTPPHPHTT LSTHVPSSST SLVTQTAHLG STTTHSEIPT
SNSTLTSIPT RLPITTLKAT GSTAPLTGTS QPQSPFTTAK ISSSQHSQTA STSHHQTTAT
HATTITPKLT TITPKLTTSD NGPTMFQSTT LTNSLPHTPH TTHSPSTGAL PSTPHTTGPP
SGTSFKTTST APTPPHPHTT LPTHVPSSST SLVTQTAHQA STQTHHSEIS TSTSRPTATA
TRLPTTTPRA TVSTSPFTMT SQGISPFTTD KTSSSLISLS SPSLTQNSSS TPPFSLSVTP
HSPNPSSVTT IFSPTNSLLP SPHLPSTTSP SSLSPSSASA HGSSSQASTW TSSIHSFTSL
TASSTPVHSF TLSSGSPTPF STLPLTTVMS TSAFPSFTLP HSTLSFTPSA QSSTPPLPLF
PTESHLPAHS TSVSSSTLRT TAHTPTPAIS SQATTRHFTA FTTQVPHPSS LSSTSGLTAT
PSSPATSFTT RHPDNTLLPT SIFPSSSFSP HGSTAASAAS SSSLVTTPPY STPGACSVRE
WQEEITFKGC TANVTMTRCE GACASSTSFN IDTQQVDTHC GCCHPLSFYE QQLELPCSDS
SVPGQRLMLT LQVFNSCACS PRGCRA
//
