ID H0WT36_OTOGA Unreviewed; 834 AA.
AC H0WT36;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
GN Name=ANAPC2 {ECO:0000313|Ensembl:ENSOGAP00000005285.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000005285.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000005285.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR EMBL; AAQR03116328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03116329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WT36; -.
DR STRING; 30611.ENSOGAP00000005285; -.
DR Ensembl; ENSOGAT00000005913.2; ENSOGAP00000005285.2; ENSOGAG00000005908.2.
DR eggNOG; KOG2165; Eukaryota.
DR GeneTree; ENSGT00390000016127; -.
DR HOGENOM; CLU_007149_2_0_1; -.
DR InParanoid; H0WT36; -.
DR OMA; FMYETFA; -.
DR TreeFam; TF105442; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0090129; P:positive regulation of synapse maturation; IEA:Ensembl.
DR GO; GO:0031915; P:positive regulation of synaptic plasticity; IEA:Ensembl.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044554; APC2-like.
DR InterPro; IPR014786; APC2_C.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR Pfam; PF08672; ANAPC2; 1.
DR Pfam; PF00888; Cullin; 1.
DR SMART; SM01013; APC2; 1.
DR SMART; SM00182; CULLIN; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 514..712
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 462..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..495
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 834 AA; 95773 MW; 55386C18EACD7E11 CRC64;
TEPRGARSWR EQMAEVTTAA EVDAHSRPGQ DMLVAWNIVS TGLVPPAALG LASSRTSGAV
PPKEEELRAA VEVLRSHGLH SVLEEWFVEV LQNDLQANIS PEFWNAIAQR ENFADEPQCL
LLLLDAFGLL ESRLDPYLRS LELLEKWTRL GLLMGTGAQG LREKVHTMLR GILFFSTPRT
FQEMIQRLYG RFLRVYMQSK RKGEGGTDPE LEGELDSRYA RRRYYRLLQS PQCAGCGSDK
QQCWCRQALE QFHQLSQVLH RLSLLERVSA EAVTTTLHQV TRERMEDRCR GEYERSFLRE
FHKWIERVVG WLGKVFLQDG PARPASPEAG NTLRRWRCHV QRFFYRIYAS LRIEELFSII
RDFPDSRPAI EDLKYCLERT DQRQQLLVSL KAALETRLLH PGVNTCDIIT LYISAIKALR
VLDPSMVILE VACEPIRRYL RTREDTVRQI VAGLTGDSDG TGDLAVELSK TDPTSLETGQ
DSEDDTGEPE DWVPDPVDAD PGRSGCRRRS SDIISLLVSI YGSKDLFINE YRSLLADRLL
HQFSFSPERE IRNVELLKLR FGEAPMHFCE VMLKDMADSR RINANIREED EKRPVEEQPP
FGVYAVILSS EFWPPFKDEK LEVPEDIRAA LETYCKKYEK LKAMRTLSWK HTLGLVTMDV
ELADRTLSVA VTPVQAVVLL YFQDQASWTL EELSKVVKMP VALLRRRMSV WLQQGVLREE
PPGTFSVIEE ERPQDRDNMV LVDSDEESDS GMASQADQKE EELLLFWTYI QAMLTNLESL
SLERIYSMLR MFVMTGPALA EIDLHELQGY LQKKVRDQQL IYSAGVYRLP KNCS
//
