ID H0WTU5_OTOGA Unreviewed; 709 AA.
AC H0WTU5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Myotubularin related protein 11 {ECO:0000313|Ensembl:ENSOGAP00000005599.2};
GN Name=MTMR11 {ECO:0000313|Ensembl:ENSOGAP00000005599.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000005599.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000005599.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; AAQR03162485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03162486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WTU5; -.
DR STRING; 30611.ENSOGAP00000005599; -.
DR Ensembl; ENSOGAT00000006270.2; ENSOGAP00000005599.2; ENSOGAG00000006266.2.
DR eggNOG; KOG1089; Eukaryota.
DR GeneTree; ENSGT00940000160276; -.
DR HOGENOM; CLU_021912_1_0_1; -.
DR InParanoid; H0WTU5; -.
DR OMA; GWQRSQD; -.
DR TreeFam; TF315197; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR CDD; cd14595; PTP-MTMR11; 1.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF51; MYOTUBULARIN-RELATED PROTEIN 11; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 196..639
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 79284 MW; 588D340C2BB6C988 CRC64;
MWWGGRGQSF NITPQKEEPE MGTVQRSRMP ELRSGQLSSS LASGCLPGEQ ILAWAPGVRK
GLEPELSGTL ICTNFRVIFQ PHGWQRHQDT PLSSEYDFAL INIGRLEAVS GLSRVQLLRP
GSLLKFIPEE ILIHGRDFRL LRVGFEAGGL EPQAFQVTVA IVQARAQSSQ AQQYVGITLS
KAGQGSGSRK PPIPLLETSE DWETERKKQG ARGWRVSTVN ERFDVATSLP RYFWVPNRIL
DSEVRRAFGH FHQGRGPRLS WHHPGGSDLL RCGGFCTASD PNKEDIRAVE AMLQAGHTDV
ILVGTTDELP ALADVQLAHL RLRALCVPES SVAEDKWLSA LEGTRWLDYV RSCLRKASDL
SVLVTSRVRS VVLQERSDRD LNGLLSSLVQ LLAAPEARTL FGFQSLVQRE WVAAGHPFLT
RLGGTGASEE APVFLLFLDC VWQLLQQYPA EFEFSEFFLL ALHDSVRVPD TLTFLRNTPW
ERGKQSGQCN SYTEVYTPGY SQPPGGNSVN LQLSVWDWDL RYSNEQILQF HNPGYDPEHC
PESWLPRQQP SFMTPGPPSS MWLFSRGALT PLNQLCPWRD SSSLLAVSSR WLPRPAISSE
SLADQEWGLP SHWGACPLPP GLLLPGYLGP QIKLWRRCYL RGKPEVQIGL SAPTISGLQD
ELFHLQELLR KWTPRVSPED HSKKRDPNTI PNPTETAGIL KGRAKGDVR
//
