ID H0WUP4_OTOGA Unreviewed; 980 AA.
AC H0WUP4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Oncostatin M receptor {ECO:0000313|Ensembl:ENSOGAP00000005976.2};
GN Name=OSMR {ECO:0000313|Ensembl:ENSOGAP00000005976.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000005976.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000005976.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR EMBL; AAQR03096877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WUP4; -.
DR STRING; 30611.ENSOGAP00000005976; -.
DR Ensembl; ENSOGAT00000006683.2; ENSOGAP00000005976.2; ENSOGAG00000006678.2.
DR eggNOG; ENOG502QWRV; Eukaryota.
DR GeneTree; ENSGT00940000160851; -.
DR HOGENOM; CLU_012673_0_0_1; -.
DR InParanoid; H0WUP4; -.
DR OMA; GKMMQYN; -.
DR TreeFam; TF338122; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0005900; C:oncostatin-M receptor complex; IEA:Ensembl.
DR GO; GO:0019838; F:growth factor binding; IEA:Ensembl.
DR GO; GO:0004924; F:oncostatin-M receptor activity; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR048497; LIF-R-like_Ig-like.
DR InterPro; IPR040817; LIFR_D2.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF95; ONCOSTATIN-M-SPECIFIC RECEPTOR SUBUNIT BETA; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF21177; LIF-R_Ig-like; 1.
DR Pfam; PF17971; LIFR_D2; 1.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..980
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003543977"
FT TRANSMEM 738..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 334..426
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 428..526
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 623..737
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 980 AA; 110461 MW; CE42BA5F7CFE9E18 CRC64;
MAFPAVFQTT CFFMLLSLRA CQSEVLTEHL PLTPEALKVF VNSTQQSLHL QWTVHNLPYK
GELKMVFQIQ ISRTETSNII WKGNYSTTVK WNEILHWSWE SELPLECATH FVRIKSVVDD
AKVPQPNIWS SWSSWQEAKV QDSFEQDTLF IFPKDKLVEE GSDVTICYIS GNIQNNISCY
LDGEQIHGEQ LDPHVSTFKL KNVPFVRERG TNIYCVDHRR NTINGGTVLF VSKVLEEPKN
FSCETQDLKT LSCTWDPGVD TTLAWSKQRS QSYYTLFESF SGKKKLCKEK NWCNWPISQD
SQAMYNFTLT AENYLRKRSV NLLFNLTDRV HPMSPLSVKF ENISATNAVM TWKVRPTGDY
LTLLCEIELY GERKMTQHNV SVKVNGKYLL SELEPDTEYA ARVRCAANHF WKWSEWSGQN
FTTLQAAPLE ALDVWRSVKS GPGTQNVTFF WKLPPKFHAN GKILHYTVIV ENLDKPSRLE
ALTIPAPANG TELTLDQSSY EIRVTASNSV GTSPASVMVI SADPGDKEVK AERIKGSKDG
FFISWKPQSG DFMGYVVDWC DHPQDTLCDF QWKNIGPNTT STVISSDAFR PGVRYNFRIY
GLSTERIAYL LEKKTGYTQE LAPLDNPQVD TINLTSHSFT LSWKNYSTES QPAFIEGYYV
YLKSKARRCH PGAEKEVLSE ITDTTVCCQY KINNPGQKTF TVENLQPESF YEFFVTPYTS
VGEGPNSTFT RVRTPDEYSY MLIRIILPVI LCIFLLLVAC NLKSQWVKEK CYPDIPDPYK
SSVLSLIKSK ENPHRTIMNI SDCIPDAIEV VNKPEGTKTQ SLGTRKSLTE TESTKPVYLY
LLPTEKNYAG PGPCICFENF TYNQAASDSG SCGHPVPVPL GALPSQLGLL TSPENLLQAP
GKNCMNSQGE IPTGETTLNY VSQLAAPVSG DKDSLPTNPL MPPPCSEYKM QMAVPFCLVS
PPLTENSGLS SMTLLGPGDH
//
