ID H0WUQ0_OTOGA Unreviewed; 360 AA.
AC H0WUQ0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Epoxide hydrolase 3 {ECO:0000313|Ensembl:ENSOGAP00000005984.2};
GN Name=EPHX3 {ECO:0000313|Ensembl:ENSOGAP00000005984.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000005984.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000005984.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Epoxide hydrolase
CC family. {ECO:0000256|ARBA:ARBA00038334}.
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DR EMBL; AAQR03128500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012664872.1; XM_012809418.1.
DR AlphaFoldDB; H0WUQ0; -.
DR STRING; 30611.ENSOGAP00000005984; -.
DR MEROPS; S33.978; -.
DR Ensembl; ENSOGAT00000006692.2; ENSOGAP00000005984.2; ENSOGAG00000006687.2.
DR GeneID; 100966277; -.
DR KEGG; oga:100966277; -.
DR CTD; 79852; -.
DR eggNOG; KOG4178; Eukaryota.
DR GeneTree; ENSGT00940000162086; -.
DR HOGENOM; CLU_020336_7_3_1; -.
DR InParanoid; H0WUQ0; -.
DR OMA; EEMHQYM; -.
DR OrthoDB; 2443908at2759; -.
DR TreeFam; TF314403; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004301; F:epoxide hydrolase activity; IEA:Ensembl.
DR GO; GO:0097176; P:epoxide metabolic process; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR000639; Epox_hydrolase-like.
DR PANTHER; PTHR43329; EPOXIDE HYDROLASE; 1.
DR PANTHER; PTHR43329:SF10; EPOXIDE HYDROLASE 3; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PRINTS; PR00111; ABHYDROLASE.
DR PRINTS; PR00412; EPOXHYDRLASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..339
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
SQ SEQUENCE 360 AA; 40848 MW; 836F7E9693CD8D4F CRC64;
MPELVVTALL APSRLSLKLL RAFMWSLVFS AALVAAAVYG CIALTHVLCR PRRGCCGRRR
RAAPACLSDP SLGEHGFLTL KSSGLRLHYV SAGQGNGPLM LFLHGFPENW FSWRYQLREF
QSRFHVVAVD LRGYGPSDAP QEVDCYTTDL LMADIQDIIL GLGYSKCILV AHDWGALLAW
NFSIYYPSLV ERMVVVSGAP MSVYQDYSLR HIGQLFRSNY MFLFQLPWLP EKLLSMSDFQ
MLKTTLTHRK KGIPHLTPNE LEAFLYNFSQ PGGLTGPLNY YRNLFRNFPL EPQELATPTL
LLWGEKDTYF ELGLVGATGS RFVPGRLEVH ILPGEGHWIP QSNPQEMHQY MWAFLQDLLN
//
