ID H0WVK3_OTOGA Unreviewed; 759 AA.
AC H0WVK3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 08-NOV-2023, entry version 61.
DE RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A3 {ECO:0000313|Ensembl:ENSOGAP00000006348.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006348.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006348.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC role in the chloride and bicarbonate homeostasis during sperm
CC epididymal maturation and capacitation.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
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DR EMBL; AAQR03011771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03011772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03011773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03011774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03011775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03011776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03011777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03011778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03011779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000006348; -.
DR Ensembl; ENSOGAT00000007091.2; ENSOGAP00000006348.2; ENSOGAG00000007084.2.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01070000253775; -.
DR HOGENOM; CLU_003182_9_4_1; -.
DR InParanoid; H0WVK3; -.
DR OMA; ALYWIPK; -.
DR TreeFam; TF313784; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR GO; GO:0051454; P:intracellular pH elevation; IEA:Ensembl.
DR GO; GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
DR GO; GO:0048240; P:sperm capacitation; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU362052};
KW Chloride {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 103..119
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 203..225
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 285..302
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 339..358
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 370..387
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 465..492
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 520..715
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 759 AA; 84171 MW; 70B2C91FBE16B349 CRC64;
MIEPFGNQYI VARPVYSAND FGEEHKKIER YHKTFLDHLK LCCSCSAQKA KGIALSLFPI
ASWLPAYRPK EWILSDIVSG VSTGLVSVLQ GLAFALLVNI SPVYGLYAAF FPCIVYFFLG
TSRHISVGKS VVELMTTHIA FSLSIYCINS KXELTNSSAS NVSLSLEERK VLVAATVSML
AGIIQLIMGV LRIGFVVVYL SESLISGFTT AAAIHVLVSQ LKFILQLQVP PHTDPFSIFK
VLESIFTQIE KTNIADLVSS LIILVIVTVF KEINQRFKSK LPVPIPIEFI MTVIATGVSY
GFDFQNRFNV SVVGKMQSGF QPPITPNAAT FQETIGDSFG IAIVAFAVAF SVASVYSLKH
DYQLDGSQEL IALGLGNIVG GAFRGFAGST ALSRSAIQES TGGKTQIAGI ISAIIVLIVI
VGIGFLLEPL QKSVLAALAL GNLKGMLMQF SEIGRLWKKD KYDCLIWIVT FILTIVLGLG
IGLGASVAFQ LLTIVFRTQF PKCSTLANVG RSNIYKNKKD YLDMYEPEGV KIFRCPSPIY
FANIGFFRQK LIDAVGFSPL RILRKRNKAL KKIRKLQKQG QLQVTPKGVI CTAYSVKDSD
EELDNNQVEE LDQPINTADL PFEIDWNADL PFNIAVPRIS IHSLILDFSA VSFLDTSSMR
GLKKILQEFL RVKVDVYIVG SDDDFIEKLT RCEFFDEEVK SSVFFLTIHD AILHILMKKD
YSTSKFNSYQ EKDTKVDFTI NTNGGLRKRE YQVPSETRF
//