ID   H0WVQ9_OTOGA            Unreviewed;       727 AA.
AC   H0WVQ9;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=ORC ubiquitin ligase 1 {ECO:0000313|Ensembl:ENSOGAP00000006409.2};
GN   Name=OBI1 {ECO:0000313|Ensembl:ENSOGAP00000006409.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006409.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000006409.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAQR03067822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003789765.1; XM_003789717.2.
DR   AlphaFoldDB; H0WVQ9; -.
DR   STRING; 30611.ENSOGAP00000006409; -.
DR   Ensembl; ENSOGAT00000007159.2; ENSOGAP00000006409.2; ENSOGAG00000007156.2.
DR   eggNOG; ENOG502QTFT; Eukaryota.
DR   GeneTree; ENSGT00390000013512; -.
DR   HOGENOM; CLU_023039_0_0_1; -.
DR   InParanoid; H0WVQ9; -.
DR   OMA; QLNPPWV; -.
DR   TreeFam; TF329331; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:Ensembl.
DR   GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR   GO; GO:0006513; P:protein monoubiquitination; IEA:Ensembl.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:Ensembl.
DR   CDD; cd16562; RING-HC_RNF219; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR039209; OBI1.
DR   InterPro; IPR035691; OBI1_RING-HC.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR14609:SF1; ORC UBIQUITIN LIGASE 1; 1.
DR   PANTHER; PTHR14609; RING FINGER PROTEIN 219; 1.
DR   Pfam; PF13923; zf-C3HC4_2; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          18..56
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          274..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          685..727
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          89..123
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          157..267
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        291..329
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   727 AA;  81056 MW;  2C8FA762D645D0BD CRC64;
     MAQTVQNVTL SLTLPITCHI CLGKVRQPVI CINNHVFCSI CIDLWLKNNS QCPACRVPIT
     PANPCKEIIG GTSESEPMLS HTVRKHLRKT RLELLHKEYE DEIDCLQKEV EELKSKNLSL
     ESQIKTILDP LTLIQDNQNE DKHLVIDNSS KIDQETVAEW KKKLRTANEI YEKVKDDVDK
     LKEANKKLKL ENGGLVRENL RLKAEVDNRS PQKFGRFTVA ALQSKVEQYE RETNRLKKAL
     ERSDKYIEEL ESQVAQLKKS GKEKEAMNSI CQRSLSADGM GGKGSEEDVA SKNQGDSASK
     QSGSSTSSSS HLAKASSSKL SDTGSARQES TINTDLNCSK NKDLYQKRVE IMLDVTDTHM
     DTYLESEWDN KPSDCVPYKD EELYDLPAPC TPLSLSCLQL STPENRESST VKAGGSIKHS
     NHLRKLVFDD FCESSSVSIK DSSEDDTNRN ENDNKSECFT TPKTGFWDCC STSYAQSLDF
     ESSEGNTIAN SVGEISSKLG EKPGSCLSKR LNSIRSFEMN RTRTSSEASM DAAYLDKISE
     LDSMMSESDN SKSPCNNGFK SVDLDGLSKS SQGSEFLGES DNLEERTKLN LSKSSLTTAD
     HLENGNEWKP TSFFLLSPSD QEMNEDFSLH PSSNPGTNET KPPSCLFQTE FSQGILLSSS
     HRLFEDQRFG SSLFKMSSEM HGLHNHLQSP WSTSFVPEKR NKNVSQSTKR KIQSSLSNAS
     PSKATKS
//