ID H0WW24_OTOGA Unreviewed; 487 AA.
AC H0WW24;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=NHERF family PDZ scaffold protein 4 {ECO:0000313|Ensembl:ENSOGAP00000006547.2};
GN Name=NHERF4 {ECO:0000313|Ensembl:ENSOGAP00000006547.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006547.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006547.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03130815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WW24; -.
DR STRING; 30611.ENSOGAP00000006547; -.
DR Ensembl; ENSOGAT00000007316.2; ENSOGAP00000006547.2; ENSOGAG00000007313.2.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00950000182849; -.
DR HOGENOM; CLU_031712_0_1_1; -.
DR InParanoid; H0WW24; -.
DR OMA; AWIPTGA; -.
DR TreeFam; TF350449; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0043296; C:apical junction complex; IEA:Ensembl.
DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
DR GO; GO:0005903; C:brush border; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0030251; F:guanylate cyclase inhibitor activity; IEA:Ensembl.
DR GO; GO:1990381; F:ubiquitin-specific protease binding; IEA:Ensembl.
DR GO; GO:0010754; P:negative regulation of cGMP-mediated signaling; IEA:Ensembl.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14191:SF20; NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF4; 1.
DR PANTHER; PTHR14191; PDZ DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00228; PDZ; 4.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR PROSITE; PS50106; PDZ; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 40..121
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 148..226
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 254..337
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 392..473
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
SQ SEQUENCE 487 AA; 52453 MW; 757CC39ACDB1307B CRC64;
PSAQSEHRGC QSRGGPVLVL LPVLCCPPPP DPRSWERLRF CLLSKEESRS FGFHLQQGRD
GAGHVVCRVE PGTSAQRQGL QEGDRILGVN SDVVEHEDYV SVVRRIRASS PRVLLTVLAR
HVYDVVRAQQ VDDAHLCPTL GPGVRPRLCH IVKDEGGFGF SVTHGYRGHF WLVLSTGGAA
ERAGVPPGAR LLEMNGVSVE KFTYNQLTRK LWQSGEQVTL LVAGPEVEEQ CRQLGVPLAA
PLAEGWALPT KPRCLHLEKG PQGFGFLLRE EKGLDGRPGQ FLREVDPGQP AEKAGMQAGD
RLVAVAGESV EGLGHEETVS RIRAQGSRVS LTVVDPAADR FFTMVRLSPL LFLKSTEVPA
SPQDTCSASL FETGDPPIAE TAEPPGPLGD HKCILYPGPG GGYGFRLSCV ANGPRLFVSQ
VTPGSSAARA GLQMGDVILE VNGYPVGGEN DLERLQQLAE AEPPLCLKLA ARSQQDWKAW
IPPGSAE
//
