ID H0WWP3_OTOGA Unreviewed; 1789 AA.
AC H0WWP3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Signal induced proliferation associated 1 like 2 {ECO:0000313|Ensembl:ENSOGAP00000006813.2};
GN Name=SIPA1L2 {ECO:0000313|Ensembl:ENSOGAP00000006813.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006813.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006813.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03135474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03135475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03135476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03135477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03135478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03135479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03135480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03135481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03135482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03135483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000006813; -.
DR Ensembl; ENSOGAT00000007618.2; ENSOGAP00000006813.2; ENSOGAG00000007607.2.
DR eggNOG; KOG3686; Eukaryota.
DR GeneTree; ENSGT00940000157388; -.
DR HOGENOM; CLU_002127_0_2_1; -.
DR InParanoid; H0WWP3; -.
DR OMA; GYRVDSY; -.
DR TreeFam; TF318626; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.1120.160; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR021818; SIPA1L_C.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF7; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF11881; SPAR_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 634..851
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 989..1065
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 44..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1168..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1726..1774
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 45..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1168..1187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1275..1302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1789 AA; 199609 MW; 8A91931E1CE931FD CRC64;
MSDPRQSQEE KHKLGRTSSK FKDSPRIMQS DDYFARKFKA INGNMGPATS LNASSSSESS
GGPVNGTPAV PKMGVRARVS EWPPKKDCSK DLTCKALWES RSQTSYESVT SVLQNGQNDQ
SDGQQEEQLD LDFVEAKYTI GDIFVHSPQR GLHPIRQRSN SDVTISDIDA EDVLDQNAVN
PNTGAALHRE YGSTSSIDRQ GLSGENFFAM LRGYRVDNYD HKAMVPFGFP EFFPCDPAIS
PSLHAAAQIS RGEFVRISGL DYMDSALLMG RDRDKPFKRR LKSESVETSL FRKLRTVKSE
HETFKFTSDL EESRLERGVR SWNCQRCFAH YDVQSILFNI NEAMATRVSV GKRKNITTGA
SAASQTQMPP GQTGTCESPL GSKEDLNSKE NLDADEGDGK SNDLVLSCPY FRNETGGEGD
RRIALSRANS ASFSSGGESC SFESSLSSHC TNAGVSVLEV PRENQPIHRE KVKRYIIEHI
DLGAYYYRKF FYGKEHQNYF GLDENLGPVA VSIRREKVED TKEKEGSQFN YRVVFRTSEL
TTLRGAILED AVPSTARHGT TRGLPLKEVL EYVIPELSIQ CLRQASNSPK VSEQLLKLDE
QGFHYKQKMG IGYMILRKDS DEVYFQNFSR SDQLEKGQRT GLSFQHKIGI LYCKAGQSTE
EEMYNNETAG PAFEEFLDLL GQRVRLKGFS KYRAQLDNKT DSTGTHSLYT TYKDYELMFH
VSTLLPYMPS NRQQLLRKRH IGNDIVTIVF QEPGALPFTP KHIRSHFQHV FVIVKVHNPC
TENVCYSVGV SRSKDVPPFG PPIPKGVTFP KSAVFRDFLL AKVINAENAA HKSEKFRAMA
TRTRQEYLKD LAENFVTTAT VDTSVKFSFI TLGAKKKEKV KPRKDAHLFS IGAIMWHVVA
RDFGQSADIE CLLGISNEFI MLIEKDSKNV VFNCSCRDVI GWTSGLMSIK VFYERGECIL
LSSVDNCAED VREIVQRLVI VTRGCETVEM TLRRNGLGQL GFHVNFEGIV ADVEPFGFAW
KAGLRQGSRL VEICKVAVAT LTHEQMIDLL RTSVTVKVVI IQPHDDGSPR RGCSELCRIP
MVEYKLDSEG TPCEYKTPFR RNTTWHRVPT PALQPLPRAS PVPGTPDRLQ CQQLLQQAQA
AIPRSTSFDR KLPDGTSLFI TSSSLNSLSK PFRSSPSNQS SSSDPGPGGS GPWRPQTLRF
WFGLKGASLL CCSSTRAQAL WSVTGPGRGR MPWMQADTQT ETKWHGPPSK VLSSYKERAL
QKDGSCKESP NKLSHIGDKS CSSHSSSNTL SSNTSSNSDD KHFGSGDLMD PELLGLTYIK
GASTDSGIDT APVSPATGHT APVGATWALP AGWGRGLKFK LWGLWFAKLS LVQLQDTVTL
SQNSSKCWWT ESNRLRMGMF SQEKSGSSPV SAANDLLADT QLTVLAFING SHHSGSPSAH
CSKNSGSLDT SKVYIVSHSS GQQVPGSVSK PYHRQGAVNK YVIGWKKSEG KIHSKLFLSS
IQRHKVRKTL ASPGLWAWPR RLRACPYPGL RLSPGVQMEK GIFSESPLVE EGRRKFSFYG
HLSPRRSLCR TLSDESICSH RRGSSFGSSR SSILDQALPN DILFSTTPPY HSTLPPRTQP
APSMGSLRNE FWFSDGSLSD KSKCTDPGLM PLPDPATGLD WSHLVDAARA FEVRRAPDFT
KPMEEKHKRH KTADSKDQLI QSEILFVKLR GWQSSERSPS TLTGKVNQLE LILRQLQTDL
RKEKQDKAVL QAEVQHLRQD NMRLQEESQT ATAQLRKFTE WFFNTIDKK
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