ID H0WWT6_OTOGA Unreviewed; 487 AA.
AC H0WWT6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=ETS variant transcription factor 4 {ECO:0000313|Ensembl:ENSOGAP00000006864.2};
GN Name=ETV4 {ECO:0000313|Ensembl:ENSOGAP00000006864.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000006864.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000006864.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03042566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WWT6; -.
DR STRING; 30611.ENSOGAP00000006864; -.
DR Ensembl; ENSOGAT00000007673.2; ENSOGAP00000006864.2; ENSOGAG00000007666.2.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000158142; -.
DR HOGENOM; CLU_030025_1_0_1; -.
DR InParanoid; H0WWT6; -.
DR OMA; DPCVPYL; -.
DR TreeFam; TF316214; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0045618; P:positive regulation of keratinocyte differentiation; IEA:Ensembl.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR006715; ETS_PEA3_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF181; ETS TRANSLOCATION VARIANT 4; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF04621; ETS_PEA3_N; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 344..424
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 135..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 487 AA; 54401 MW; 7E0EDAB61673FE54 CRC64;
MERRMKGGYL DQQVPYTFCS KSPGNGSLRE ALTVPQGKLM DPSSLPPPDS EDLFQDLSHF
QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ SPCTDPALSC SRRPPLPYHH
GEQCLYSSAY DPPRQIAIKS PTPSAPGQSP LQPFPRAEQR SFLRSSNTSQ PHPGHGYLGE
HSSVFQQPLD ICHSFTSSPG GGGREPLPAP YQHQLSEPCP PYPQQSFKQE YHDPLYEQAG
QPAMGQAGVN GHRYPGAGVV IKQEQTDFTY DSDVTGCASM YLHTEGFSGP SPGDGVMEGY
GYEKPLRPFP DDVCVVPEKF EGDIKQEGIG TFREGPPYQR RGALQLWQFL VALLDDPTNA
HFIAWTGRGM EFKLIEPEEV ARLWGIQKNR PAMNYDKLSR SLRYYYEKGI MQKVAGERYV
YKFVCEPEAL FSLAFPDNQR PALKAEFDRP VSEEDTVPLS HLDESPAYLS ELAGPAQPFG
PKSGYSY
//
